26-01-2016, 11:23 PM
(26-01-2016, 10:25 PM)Lotus Wrote:(26-01-2016, 07:28 PM)Lotus Wrote:(26-01-2016, 03:09 PM)elainecd Wrote: peony root extract has helped my areolas both in size and color. At least I think they have. If I don't do it once a day they def go back smaller.
Cool,
White peony inhibits the 5 alpha reductase enzyme (from the conversion to DHT) in the sebaceous glands, which produces sebum. Sebaceous glands are bunched around the areolas, a topical solution would work too, imo. But, I'd add a pro-aromatase, pro-ERa like red clover. I've done this before and blew up my areolas.
Thanks Elaine, good to hear from you.
I think lemon and orange peel could work too, try it. the fact they inhibit DHT (CYP17 inhibitor) makes sense too.
(22-01-2016, 05:31 AM)Lotus Wrote: In conclusion, we suggest in the present study that the supplementation with lemon polyphenols suppressed body weight gain and body fat accumulation by increasing the peroxisomal β-oxidation, which was likely mediated via up-regulation of the mRNA levels of PPARα in the liver. In addition, the levels of serum insulin, glucose and leptin were significantly improved by lemon polyphenols, thereby improving the insulin resistance. We suggest that a supplementation with lemon polyphenols may prevent or improve obesity and insulin resistance by modulating lipid metabolism and preventing metabolic syndrome as a representative, lifestyle-related cluster of diseases caused by an excessively high fat diet.
Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue
http://www.ncbi.nlm.nih.gov/pmc/articles...43-201.pdf
Topical spiro is a Pharma example of eliminating DHT in the sebaceous gland
spironolactone inhibits dihydrotestosterone receptors in human sebaceous glands: an autoradiographic study in subjects with acne vulgaris.
Berardesca E1, Gabba P, Ucci G, Borroni G, Rabbiosi G.
Author information
Abstract
The interaction between spironolactone and dihydrotestosterone (DHT) receptors was evaluated with an autoradiographic technique. The inhibition of DHT receptors by spironolactone was found to be related to the decrease of tritiated DHT granules in the sebaceous glands of the treated site. 6 male patients affected by acne vulgaris entered the study. The acute study was performed by applying to 25 cm2 of the back a cream containing 5% spironolactone under occlusive dressing. The dosage of spironolactone applied was 4 mg/cm2 for 48 h. The long-term study was performed by applying the same amount to the entire back, without occlusion, twice daily for 1 month. Skin biopsies were taken at the end of the treatment, incubated with tritiated DHT and processed for autoradiography. Both the acute and the long-term study revealed a decrease of the autoradiographic granules in the treated site. This effect is related to the binding of spironolactone with dihydrotestosterone receptors in the sebaceous glands. Our study demonstrates that 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies.
PMID: 2972662 [PubMed - indexed for MEDLINE]