[missboobshirt]

five finger death punch! omg memories lol!

[Lotus]

Here we go, any test subjects?.......another find. I hope ya'll like it. I did try this!, and tbh, it perked my boobs up lol.


Dehydroepiandrosterone (DHEA) is the principal human C-19 steroid. DHEA has very low androgenic potency, but serves as the major direct or indirect precursor for most sex steroids. DHEA is secreted by the adrenal gland and production is at least partly controlled by adrenocorticotropic hormone (ACTH). The bulk of DHEA is secreted as a 3-sulfoconjugate dehydroepiandrosterone sulfate (DHEAS). Both hormones are albumin bound, but DHEAS binding is much tighter. As a result, circulating concentrations of DHEAS are much higher (>100-fold) compared to DHEA. In most clinical situations, DHEA and DHEAS results can be used interchangeably. In gonads and several other tissues, most notably skin, steroid sulfatases can convert DHEAS back to DHEA, which can then be metabolized to stronger androgens and to estrogens.

DHEA is C-19 steroid (androgen) but has a very low potency (note to missB). Supplemental DHEA raises estrogen in men and post menopausal women. But it can also raise androgens (DHT) in some, experienced users know how much to use. DHEA applied topically helps restore breast atrophy in an animal study (see below). I found this in another forum, and it describes an animal study using a topical application of DHEA that restored atrophy of the breasts and stimulates lobuloalveolar and ductal growth........boob growth. The author (haidut, smart fella btw) suggests a 15mg significantly increases all estrogens. Used daily?, I'd be inclined to say a few times per week to start.

The breast size increase was similar to that observed in pregnancy/lactation, so it corresponds to a pretty significant increase of 1-3 digits in cup size. Finally, DHEA did not just increase breast size but it completely reversed the breast atrophy and other negative tissue changes seen in ovariectomized animals (a rodent model of menopause).

From the study,
DHEA treatment was characterized by a marked stimulation of the ductal and mainly the lobular structures. In addition, epithelial cell hypertrophy and a marked stimulation of secretory activity were seen, these effects being accompanied by the accumulation of clear and eosinophilic vacuoles in the cytoplasm of the acinar cells. -


DHEA stimulated lobuloalveolar and ductal growth, as well as the secretory activity of the acinar cells, thus resulting in a lobuloalveolar type of development of the mammary gland. - See more at: http://press.endocrine.org/doi/10.1210/endo.139.2.5762?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&#sthash.0mwEgt3M.dpuf

[Lotus]

So this is making me think about compounding a formula that you can make at home. Dietary DHEA supplements disolve fast, I think a combination in oil?, maybe with a pro-Aromatase, a green tea oil would fit imo, only that's not ready available.


Smart people, any ideas?

[Lotus]

So this is making me think about compounding a formula that you can make at home. Dietary DHEA supplements disolve fast, I think a combination in oil?, maybe with a pro-Aromatase, a green tea oil would fit imo, only that's not ready available.


Smart people, any ideas?

I've got it, tequila. It's a pro-aromatase, which would help this solution against skin 5ar, and as we know, DHT in skin can be upregulated by 5ar (alpha reductase), in other words, a major target tissue of DHT production (aka zits, male pattern baldness, anti-breast growth etc).

Tamer?, olive oil.

[Lotus]

2 studies, simalr effect. In any event DHEA looks like it can build a bigger butt, and....,the way it looks, mr. happy can benefit from a topical DHEA solution, oops!


Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo.
Son ED1, Lee JY, Lee S, Kim MS, Lee BG, Chang IS, Chung JH.
Author information

* 1Amorepacific Corp/R&D Center, Gyeonggi-do, Korea.
Abstract
To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular matrix proteins in aged human skin, 17beta-estradiol (0.01%) and its vehicle (70% propylene glycol, 30% ethanol) were applied to aged (68-82 y, eight females and five males) human buttock skin under occlusion for 2 wk (three times per week). Topical 17beta-estradiol was found to increase the expression of type 1 procollagen mRNA and protein significantly in human aged skin in vivo. In addition, metalloproteinase (MMP-1 protein levels were reduced by topical 17beta-estradiol. The expressions of TGF-beta1, TGF-beta type II receptor, and Sma and Mad related (Smad)3 were increased by topical 17 beta-estradiol in aged human skin, and TGF-beta1 neutralizing antibody inhibited 17beta-estradiol-induced procollagen synthesis in cultured fibroblasts. We also found that the expressions of tropoelastin and fibrillin-1 mRNA and protein, and elastic fibers in aged skin were also increased by topical 17beta-estradiol. Topical 17beta-estradiol also increased keratinocyte proliferation and the epidermal thickness in aged human skin. We also observed the same effects of topical 17beta-estradiol in young skin. In conclusion, our results suggest that topical 17beta-estradiol treatment may improve the cutaneous function of aged human skin by improving the connective tissue and increasing epidermal thickness.
PMID: 15955089 [PubMed - indexed for MEDLINE]


Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin.
Shin MH1, Rhie GE, Park CH, Kim KH, Cho KH, Eun HC, Chung JH.
Author information

* 1Department of Dermatology, Seoul National University College of Medicine and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, 28 Yungon-dong, Chongno-Gu, Seoul 110-744, Korea.
Abstract
Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced human adrenal steroids to be reduced with age. DHEA may be related to the process of skin aging through the regulation and degradation of extracelluar matrix protein. In this study, we demonstrate that DHEA can increase procollagen synthesis and inhibit collagen degradation by decreasing matrix metalloproteinases (MMP)-1 synthesis and increasing tisuue inhibitor of matrix metalloprotease (TIMP-1) production in cultured dermal fibroblasts. DHEA was found to inhibit ultraviolet (UV)-induced MMP-1 production and the UV-induced decrease of procollagen synthesis, probably due to the inhibition of UV-induced AP-1 activity. DHEA (5%) in ethanol:olive oil (1:2) was topically applied to buttock skin of volunteers 12 times over 4 weeks, and was found to significantly increase the expression of procollagen alpha1(I) mRNA and protein in both aged and young skin. On the other hand, topical DHEA significantly decreased the basal expression of MMP-1 mRNA and protein, but increased the expression of TIMP-1 protein in aged skin. We also found that DHEA induced the expressions of transforming growth factor-beta1 and connective tissue growth factor mRNA in cultured fibroblasts and aged skin, which may play a role in the DHEA-induced changes of procollagen and MMP-1 expression. Our results suggest the possibility of using DHEA as an anti-skin aging agent.

(Source-cantstopeating, ray peat forum)

[missboobshirt]

oh wow.. lotus, thanks!!! ;__; that was awesome of you. So DHEA at 9.4 ng/mL isn't so bad then at a normal range of 1.3 - 9.8 ng/mL. ? I was reading online that DHEA was in a group called the "fountain of youth" hormones, everything that you wrote makes me believe that it might be Maca that raised it.. (unless thats just the way my DHEA is) but you said DHEA can help build the butt and ever since taking more amino acids I went from 36" to 43" -- other than that I can't think of anything I take that would effect it.

http://www.livestrong.com/article/517189...oost-dhea/

oop! would you look at that

thanks Maca you did it again.

also, http://bodyecology.com/articles/avoid_ea...g_dhea.php

maybe my fish oil too.

http://www.buzzle.com/articles/how-to-in...rally.html

so it sounds like DHEA is okay.

[pom19]

Thanks Lotus, and missboobshirt for the info. POM

[Lotus]

Great info missB, thanks.

Thanks Lotus, and missboobshirt for the info. POM

Thanks Pom.

[pom19]

Great info missB, thanks.

Thanks Lotus, and missboobshirt for the info. POM

Thanks Pom.

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[elainecd]

peony root extract has helped my areolas both in size and color. At least I think they have. If I don't do it once a day they def go back smaller.