(16-09-2022, 11:15 PM)Vicki_1975 Wrote: Took my First PM today. Should I stop the FG or reduce it?
Hi Vicky.
Please list how much FG you take and the manufacture. FG is estrogenic and high in protein Saw Palmetto down regulates progesterone receptors.
(16-09-2022, 11:15 PM)Vicki_1975 Wrote: Took my First PM today. Should I stop the FG or reduce it?
Hi Vicky,
Please list how much FG you take and the manufacture. FG is estrogenic (via Diosgenin) and high in protein and helps to upregulate progesterone receptors, Saw Palmetto down regulates progesterone receptors. Personally? I'd get rid of saw palmetto as it only inhibits DHT 32%, red reishi inhibits DHT 80-90%. Here's a post from a thread I have at Breastnexus (the ladies forum) on Fenugreek. I have further studies/information on fenugreek, but judging from your result I'd say stay on FG, and don't start taking PM for a few reason. Other7 reasons are the fact that the phytoestrogens in PM (miroestrol/deoxymiroestrol) are different from the phytoestrogens in Fenugreek (Diosgenin), their competing for the same receptor. Plus FG lowers insulin and reduces inflammation, PM actually increases systemic inflammation (shows up as increased white blood cell count and basophils).
There's no need to push the envelope here with having a few risk factors, low T, being a little overweight (no offense) and age. Adding PM certainly adds to the possibility of developing DVT (deep vein thrombosis) which others here can share in there experience with it.
Concerning your lab work, please re-check your numbers again, normally when posting labs you'll want to post the values attached to each, for instance:
Your labs would look like this:
SHBG 15.86 nmol/L
You're Testosterone will be one specific number, and then it'll list a reference range (a low end, and a top end) see the attached diagram. If we take the low end of T you listed at 238 ng/dL and plug it in to the testosterone calculator chart (found online) we come up with the following:
Total Testosterone 238 ng/dL
Free T 6.69 ng/dL 2.81%
Which is pretty good lab results in my opinion.
(28-04-2016, 04:39 AM)Lotus Wrote: I posted this last year, take a look at the diagram in table 2, in specifically the increase in dhea, progesterone, FSH (follicle stimulating hormone---a pure aromatase imo) testosterone and prolactin, respectively. From the study I believe the bump in libido comes from DHEA (similar to maca), however, the way FG increases E2 (dramatically in month 2) comes from its aromatase capabilities (from multiple pathways I believe), but mostly from FSH.
(26-08-2015, 09:41 PM)Lotus Wrote: Influence of a Specialized Trigonella foenum- graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study
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The aim of the study was to evaluate the effect of Trigonellafoenum-graecum (fenugreek) seed extract on sex hormones and sexual function in healthy menstruating women who reported low sexual drive. This short term, single site, double blind, randomised, placebo-controlled study was conducted on 80 women, aged 20 to 49 years. Participants were randomised to either an oral dose of a standardised T. foenum-graecum seed extract (libifem) at a dose of 600 mg/day or placebo over two menstrual cycles. Dehydroepiandrosterone sulfate, progesterone, androstenedione, total and free testosterone, estradiol (E2), luteinizing hormone, follicle stimulating hormone, sex hormone binding globulin and cholesterol were measured at baseline and 8 weeks. The individual aspects of sexual function were measured using the Derogatis interview for sexual functioning and female sexual function index self-administered questionnaires. Stress, fatigue and quality of the relationship with partner were also measured using the PSS (Perceived Stress Scale), MFI-20 (Multidimensional Fatigue Inventory) and DAS (Dyadic Adjustment Scale) quality of life measures, respectively. There was a significant increase in free testosterone and E2 in the active group as well as sexual desire and arousal compared with the placebo group. The results indicate that this extract of T. foenum-graecum may be a useful treatment for increasing sexual arousal and desire in women. Copyright © 2015 John Wiley & Sons, Ltd.
https://www.researchgate.net/profile/Luis_Vitetta/publication/275354668_Influence_of_a_Specialized_Trigonella_foenum_graecum_Seed_Extract_Libifem_on_Testosterone_Estradiol_and_Sexual_Function_in_Healthy_Menstruating_Women_a_Randomised_Placebo_Controlled_Study/links/553ae3960cf2c415bb08fe6d/Influence-of-a-Specialized-Trigonella-foenum-graecum-Seed-Extract-Libifem-on-Testosterone-Estradiol-and-Sexual-Function-in-Healthy-Menstruating-Women-a-Randomised-Placebo-Controlled-Study.pdf
(27-08-2015, 12:17 AM)Lotus Wrote: Well yeah, but judging from this study FG pretty much upregulates everything, see here:
Administration of T. foenum-graecum seed extract was also associated with a significant increase in E2 levels. Estradiol stimulates vaginal lubrication and blood flow, affecting a woman’s capacity for sexual arousal and orgasm (Simon, 2011); this supports the significant positive change in sexual arousal observed. Whilst the mechanism of the increase in E2 levels is unclear from the current study, one possibility is due to increased aromatase activity that converts testosterone to E2.
my interpretation of how FG increases E2 is explained above.