What do you mean by "aromatase up regulator"?

Aromatase

1. an adrenal enzyme that converts androstenedione and estrone to estrogen. Inhibiting its action is one approach to breast cancer prevention and treatment.
   

 Upregulation 
         1.the process of increasing the response to a stimulus specifically : increase in a cellular response to a molecular stimulus due to increase in the number of receptors on the cell surface.



Another term that is important to grasp is


Agonist 
           1. a substance which initiates a physiological response when combined with a receptor.



Selective estrogen receptor modulator
*(stimulate estrogen-like action in various tissues)*


Bovine Ovary and White Peony are aromatase upregulators/Agonist while Dandolin would be classified as a SERM ( Selective Estrogen Receptor Modulator aka)


FROM AN OLD POST SEE BELOW 

Pandora56

[quote pid='204373' dateline='1543343927']

I have done some research on the dandelion root

https://www.meltchestfat.com/what-is-dandelions-and-does-it-help-get-rid-of-man-boobs-really/

from what i see now i dont want this … “dandelion is know as a armotase inhibitor ..meaning it blocks estrogen ” the root act as a estorgen but it blocks other photoestogens which means opposite effect for a person who wants breast growth-can even be suggest to men for reducing man boobs 

Interesting, I remember Lotus recommending it and many others were seeming to have positive effects. I found on websites stating its a phytoestrogen. Perhaps its the greens(Flowers) that cause the anti-estrogen effects but the root itself does not, as the article said Dandelion but never said anything about the root. 

I also found this 

https://www.ncbi.nlm.nih.gov/pubmed/26614455

Ethanolic extract of dandelion (Taraxacum mongolicum) induces estrogenic activity in MCF-7 cells and immature rats.
Oh SM1, Kim HR2, Park YJ2, Lee YH1, Chung KH3.
Author information

Abstract
Plants of the genus Taraxacum, commonly known as dandelions, are used to treat breast cancer in traditional folk medicine. However, their use has mainly been based on empirical findings without sufficient scientific evidence. Therefore, we hypothesized that dandelions would behave as a Selective estrogen receptor modulator (SERM) and be effective as hormone replacement therapy (HRT) in the postmenopausal women. 

In the present study, in vitro assay systems, including cell proliferation assay, reporter gene assay, and RT-PCR to evaluate the mRNA expression of estrogen-related genes (pS2 and progesterone receptor, PR), were performed in human breast cancer cells.

Dandelion ethanol extract (DEE) significantly increased cell proliferation and estrogen response element (ERE)-driven luciferase activity. 

DEE significantly induced the expression of estrogen related genes such as pS2 and PR, which was inhibited by tamoxifen at 1 μmol·L(-1). These results indicated that DEE could induce estrogenic activities mediated by a classical estrogen receptor pathway.

In addition, immature rat uterotrophic assay was carried out to identify estrogenic activity of DEE in vivo. The lowest concentration of DEE slightly increased the uterine wet weight, but there was no significant effect with the highest concentration of DEE. The results demonstrate the potential estrogenic activities of DEE, providing scientific evidence supporting their use in traditional medicine.

~and this~

https://www.ncbi.nlm.nih.gov/pubmed/17671731

Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice.
Zhi X1, Honda K, Ozaki K, Misugi T, Sumi T, Ishiko O.
Author information

Abstract
Reproductive hormones exert their actions via receptors in diverse tissues. In this study, we examined the expression of estrogen receptors (ERalpha and ERbeta), progesterone receptor (PR), and follicle-stimulating hormone receptor (FSHR) in the adipose tissue and reproductive organs of mice following oral treatment with Dandelion T-1 extract (DT-1E) for 6 weeks. 

Quantitative assays by real-time reverse transcription polymerase chain reaction showed enhanced expression of ERalpha and ERbeta mRNA in the adipose tissue of mice fed a diet containing DT-1E compared with the control group fed a plain diet. Furthermore, following gonadotropin injection, higher mRNA expression of ERalpha, ERbeta and PR in the uterus and FSHR in the ovary was found in the DT-1E group compared with the control group. An immunohistochemical study also showed increased levels of the above-mentioned receptors in the DT-1E group. 

The present study shows that oral intake of DT-1E up-regulates ERalpha, ERbeta, PR and FSHR expression in mice, suggesting the potential application of DT-1E for the clinical treatment of reproductive hormone-related disturbances.

I did find supporting evidence about it being a slight Aromatase Inhibitor

Please See Table 1 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/

You will notice with this chart they clearly state which plants and funguses are inhibitors and dandelion while it certainly inhibits armoatase it isn't as strong as others. 

So it upregulates estrogenic receptors but diminishes aromatase abilities. I wonder how the BO and White Peony respond considering they are extremely strong aromatase upregulators.  I guess we need to figure out if upregulating the estrogen receptors is worth the offset?  I might be completely wrong as I am no biology major and would need to test this on myself. 

[/quote]


I have tested this for myself and noticed that Dandelion helps assist my NBE program so I take it twice a day morning and Evening.

I’d read the “Breast Growing Notes” thread. 

Great Info!

Thanks everyone.

So, how does that sound:

BO x4 (1,000 mg) : https://www.swansonvitamins.com/swanson-premium-raw-ovarian-glandular-250-mg-60-caps
Pituitary Glandular x4 (320 mg) : https://www.swansonvitamins.com/swanson-premium-raw-pituitary-glandular-80-mg-60-caps
Dandelion x1 (1,260mg) : https://www.swansonvitamins.com/natures-answer-dandelion-root-90-veg-caps
Saw palmetto x2 (1,080 mg) : https://www.swansonvitamins.com/swanson-premium-saw-palmetto-540-mg-250-caps
Chasteberry Fruit x2 (800 mg) https://www.swansonvitamins.com/swanson-premium-chasteberry-fruit-400-mg-120-caps


(Swanson don't carry white peony supplements, only tea.)

Thanks everyone.

So, how does that sound:

BO x4 (1,000 mg) : https://www.swansonvitamins.com/swanson-premium-raw-ovarian-glandular-250-mg-60-caps
Pituitary Glandular x4 (320 mg) : https://www.swansonvitamins.com/swanson-premium-raw-pituitary-glandular-80-mg-60-caps
Dandelion x1 (1,260mg) : https://www.swansonvitamins.com/natures-answer-dandelion-root-90-veg-caps
Saw palmetto x2 (1,080 mg) : https://www.swansonvitamins.com/swanson-premium-saw-palmetto-540-mg-250-caps
Chasteberry Fruit x2 (800 mg) https://www.swansonvitamins.com/swanson-premium-chasteberry-fruit-400-mg-120-caps


(Swanson don't carry white peony supplements, only tea.)

Taking all that saw palmetto can affect the way BO can function from what I have grasped reading. I just crack a pill and drink water with it throughout the day just to subtly control any DHT not being fully converted. 

Most people who take bo don't even use Saw palmetto, this is just something I have found to work for me.

F*** Me! I'M Not Ever Trying Anymore Raw Ovarian Glandular it's a waste of time! 

I'M at the point I would rather just go on HRT and forget all these supplements!

Right the best option is hrt but some can't you have to deal with approval of others to get needed letter's ,and the full on dedication of living as a woman around your family work,freinds , so Bambi how long did you attempt BO ?

Well the first time i had 10 bottles that was back in 2017 or some where around that year anyways it was working then but this last time it was like a tiny bit i felt and the rest was nothing. I need to let my body try to reset for a while and then get on something that might work.