Here's a good article about "Dermal Fatigue", creams and hormones.
dermal absorption fatigue” - meaning it may absorb well from that location for awhile, but then not as well over time. (In other words, change locations periodically)
Hormone creams can be rubbed on the inner and outer arms (upper and lower), the backs of the hands (if you are not going to wash your hands for at least 4 hours!), the top of the foot, the inner thigh, neck, abdomen, even face. Just spread out the cream and gently rib it in until the area is slightly dry to the touch. Wait a few minutes before putting clothes on over the area.
As for
mucosa, women have the inside of the external labia, the vaginal opening and vaginal canal. Men and women both can use the anal opening for hormone creams, since it absorbs well there. For troches or sublingual drops, under the tongue or between the cheek and gum is another mucosal surface that can absorb hormones well, but it is important to try not to swallow them. For mucosal application, the hormones are generally compounded into a smaller amount of cream, so that there is less to apply.
Estrogens should not be taken by mouth since this causes a
pro-inflammatory state
which can pre-dispose to blood clots and other problems. It is best to deliver bioidentical estrogens through a transdermal cream or sublingual drops. Some doctors have compounded bioidentical Estradiol into a capsule for oral delivery, but I do not recommend this. Bioidentical Estradiol is available from the pharmaceutical industry as a patch (they couldn’t patent the hormone itself, but did patent the patch delivery system), but the dose is not as adjustable as the cream, and it does not contain any of the breast-protective Estriol that most bioidentical doctors add in a combination called Biest – meaning two kinds of estrogen – Estradiol plus Estriol. Estrogen should not be rubbed on the breasts, but Progesterone can go there.
It is always important to take oral hormones on an
empty stomach, which means one hour before, or two-three hours after a meal. However, two hormones can be taken at the same time, such as Thyroid and Cortisol in the morning.
The classic oral hormones are natural
Thyroid – such as Armour or Naturethroid which contain both T3 and T4 (the two naturally occurring thyroid hormones), as opposed to Synthroid, Levothroid, or L-Thyroxin which only contain T4. T3 is a short-acting hormone, which is why it is better to dose natural thyroid twice or even three times per day. I recommend keeping your bottle of natural thyroid by your bedside, so that you can take it when you first get up, and again before bed. Alternatively, the second dose can be taken an hour before dinner if you have trouble sleeping after taking it at night.
DHEA can be swallowed at night (to help calm over-active adrenals at night) or in the morning, and can be compounded into a cream as well.
Cortisol, brand name Cortef (generic Hydrocortisone) can be taken orally as a small white tablet. It is also relatively short-acting, so can be dosed approximately every 4-6 hours during the day, but not later than 3-4 pm or it may cause insomnia.
Pregnenolone can be taken by mouth in the morning.
How to Take Your Bioidentical Hormones
http://www.optimalhealthspectrums.com/wp...rmones.pdf