The health benefits of phyto's are well documented (especially here). These intracellular pathways are very interesting to say the least. That fact that someone did these kinds of studies blows me away lol. The estrogen receptor bioavailability chart I listed on another thread ties into these two studies. Put them all together and you get the sense of a reality check of sorts on NBE. The takeaway is that this info explains why we have slow, or no growth at all for some. Plus, I would even go as far to say the same holds true for HRT, and that glaring fact was E2 wasn't strong at binding to ER-a (the growth receptor). Which explains why HRT is slow going too, which if I did HRT I'd add these things below, that's just my opinion though. Estradiol (E2) doesn't all get bound to the estrogen receptors.
Consider this though, increased levels of phyto's block out the body's own "natural estrogens", I'd say that's something you can ill afford when trying to grow breasts.
I think the obvious choice is to balance herbs that are PRO-ER-a with ER-b (protective receptor). Turmeric, green tea, essential fatty acids, and certain phtyoestrogens. 5 ar inhibitors are still a viable choice, reishi binds to ER's, not sure which one yet. WP is still a good choice. New weapons are things like 17 beta HSD's, type 1 & 4, plus CYP19 is still a viable option considering the andro to estro pathway,(that backdoor pathway is yet to be tapped).
cAMP or cyclic adenosine monophosphate is another possible NBE tool. Imo cAMP ties into fatty acids, or in large part how cAMP delivers FA's to hormones. In other words increasing blood flow to the receptors increase their bioavailability. Forilskin comes to mind, but quite honestly I think fatty acids work quite the same way.
cAMP is a second messenger important in many biological processes. cAMP is derived from adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway.
cAMP is a second messenger, used for intracellular signal transduction, such as transferring the effects of hormones like glucagon and adrenaline, which cannot get through the cell membrane. Its purposes include the activation of protein kinases and regulating the effects of adrenaline and glucagon. It is also used to regulate the passage of Ca2+ through ion channels.
cyclic adenosine monophosphate
http://psychology.wikia.com/wiki/Cyclic_...ophosphate
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Bottom line- low dose esstential fatty acids (eg-EPO) 2000 mg and 2000 mg omega 3's, coconut oil 2000 mg will have a big effect on ER-a bioavailability over straight use of phytoestrogens. And for more depth, RC, Vitex, Hops all have an ER-alpha affinity. Balance with turmeric, green tea, progesterone, WP, reishi and boobie friendly foods that's been shared and its a solid program.
Massage, yoga, walking, hydration, etc are needed too. Remember, not everyone carries the same growth genes (DNA) for breast growth, meaning some are more sensitive to ER-a's over others. But!!!!, you absolutely "DO NOT" want to put yourself at risk with crazy herb dosages. If you've spent all this time and money on growing those boobs then why wouldn't you want an insurance policy ( eg-protective measures against breast cancer[tumeric,green tea]) which can even happen with
phytoestrogens, (always proceed with caution).
Research research, get all the facts, weigh all the options and then make an informed decision on an NBE program. 95% of that info is already here in the NBE archives, yup!, you gotta read it. And as always check with your primary care Doc.