[MonikaT]

I think there are some who take 1000 mg twice a day. I think for most people, it is a matter of tolerance. Some people suffer withdrawal symptoms of a sort if they go too long between doses. Others, like me, have intestinal issues tolerating PM so spreading the dose throughout the day works better. Unlike some people, I have no issues with back or kidney pain from taking PM at bedtime. Given that hormone levels are highest first thing in the morning, there is some justification to take one big dose in the morning and be done for the day. If it works better for you, I don't think you're hurting anything by taking two larger doses rather than four smaller ones.