[MonikaT]

I did some math and it's discouraging. In this study the paeoniflorin concentration they used was 100 mcg/ml. In mice, giving them 10 mg paeoniflorin/kg bodyweight yielded a maximum blood concentration of 111 ng/ml. So using linear extrapolation, to get 100 mcg/ml in mice you'd have to give them 9009 mg paeoniflorin/kg bodyweight. To get the human equivalent dose you divide by 12.3 (to account for the mouse's faster metabolism) and get 732 mg paeoniflorin/kg bodyweight. That is an insane amount, so this study isn't very helpful for dose determination. One can only hope that lower doses will still have an effect.

In rats, a dose of 300 mg paeoniflorin/kg bodyweight resulted in 3.69 mcg/ml. So to get to 100 mcg/ml they'd need 8130 mg/kg. Divide by 6.2 to get the human equivalent dose and we get 1311 mg/kg, which is an even more discouraging number.

Candace,

I just read the abstract you referenced. It seems they arbitrarily chose 100mcg/ml and had profound results. That tells me it probably doesn't require that kind of dosing to see some sort of desired result. I'm not sure what they were trying to prove or why, but it certainly isn't for purposes of finding a good human dose to cause aromatization in males so they can grow breasts or to lower excessive T in human females.