19-09-2014, 01:42 AM
(19-09-2014, 12:52 AM)Candace Wrote: I did some math and it's discouraging. In this study the paeoniflorin concentration they used was 100 mcg/ml. In mice, giving them 10 mg paeoniflorin/kg bodyweight yielded a maximum blood concentration of 111 ng/ml. So using linear extrapolation, to get 100 mcg/ml in mice you'd have to give them 9009 mg paeoniflorin/kg bodyweight. To get the human equivalent dose you divide by 12.3 (to account for the mouse's faster metabolism) and get 732 mg paeoniflorin/kg bodyweight. That is an insane amount, so this study isn't very helpful for dose determination. One can only hope that lower doses will still have an effect.
In rats, a dose of 300 mg paeoniflorin/kg bodyweight resulted in 3.69 mcg/ml. So to get to 100 mcg/ml they'd need 8130 mg/kg. Divide by 6.2 to get the human equivalent dose and we get 1311 mg/kg, which is an even more discouraging number.
Oy, that IS discouraging. Perhaps with everything else I take, I can get by with less given how expensive white peony supplements can be. Mountain Rose is fairly inexpensive, $12/lb of bulk root, but then it isn't standardized, and I don't have time to process it and encapsulate. Sadly, licorice root is too dangerous for me since I tend to have issues with high BP.
Thanks, Candace. Btw, I saw in another thread you had a similar thought to mine regarding LEF selling white peony for immune support. What really surprised me is that they were on a big kick about low T a few years ago, and now they are actively promoting something that is known to promote aromatization. Then again, they also prefer topical, bio-identical T which can also aromatize in the skin. I'm really starting to wonder about them.
I'm still curious if anyone is using peony and getting results. I might never see results or need it. My free T is in the female range. Not sure where my E is. The only way my doctor and insurance will test is if I admit I'm getting breast pain, and then the doc will want to stop it, if my E is too high. I'm getting the results I want, I guess, but it took 18-24 months just to get breast buds.