[Candace]

I did some math and it's discouraging. In this study the paeoniflorin concentration they used was 100 mcg/ml. In mice, giving them 10 mg paeoniflorin/kg bodyweight yielded a maximum blood concentration of 111 ng/ml. So using linear extrapolation, to get 100 mcg/ml in mice you'd have to give them 9009 mg paeoniflorin/kg bodyweight. To get the human equivalent dose you divide by 12.3 (to account for the mouse's faster metabolism) and get 732 mg paeoniflorin/kg bodyweight. That is an insane amount, so this study isn't very helpful for dose determination. One can only hope that lower doses will still have an effect.

In rats, a dose of 300 mg paeoniflorin/kg bodyweight resulted in 3.69 mcg/ml. So to get to 100 mcg/ml they'd need 8130 mg/kg. Divide by 6.2 to get the human equivalent dose and we get 1311 mg/kg, which is an even more discouraging number.