[Lotus]

I like your new avatar Lotus. POM

Thanks Pom,

[GoneGirl]

I'm glad you're still with us, Lotus, raising our endo awareness with each and every post. I know we've had some disagreements in the past, but on balance, I know that you are a huge asset to this forum. If anyone should question their presence on this forum it should be me who has moved quickly beyond NBE into a world that most here are not ready to embrace. I want to stick around, though, because there are many members here that I care about, and that includes you, Lotus. Please accept my apologies for any past affront.

Hugs,

Clara

[Lotus]

I'm glad you're still with us, Lotus, raising our endo awareness with each and every post. I know we've had some disagreements in the past, but on balance, I know that you are a huge asset to this forum. If anyone should question their presence on this forum it should be me who has moved quickly beyond NBE into a world that most here are not ready to embrace. I want to stick around, though, because there are many members here that I care about, and that includes you, Lotus. Please accept my apologies for any past affront.

Hugs,

Clara h

Hi Clara,

I'm glad to see you back, your last post before your absence seemed like you were taking a break?. I think this is a fair statement and hopefully you'll agree, "we're all part of the same team," albeit in different positions.

Thank you for your kind words and apology, (it's very humbling) my apologies too. I'm also glad we got all those (feelings) out in the open, (yes really, lol). Moving forward we know (hopefully) how some members feel, I don't believe we'll have to walk on crushed egg shells to keep harmony, somewhere in the middle maybe, lol. (Btw, credit to kari, Annabel, Sammy for their wisdom and support).

What a terrific opportunity for Breast-Nexus to offer an embrace instead of fear, hatred, isolation (fill in the blanks) to new or even existing members, who are either on one side of the fence or other, or even sitting on the fence with love and support. We have people hurting out there and who need help, with all the love and support hopefully it can help, the world is our oyster as they say, lol.


Ps. What do think of Eve's restructuring?, (of course I like it, no bias here, lol), honestly once you get the hang of it, it's pretty seamless.

L

[GoneGirl]

Ps. What do think of Eve's restructuring?, (of course I like it, no bias here, lol), honestly once you get the hang of it, it's pretty seamless.

L

I think it's a huge improvement, Lotus. I was pleased to see what Eve has done (with your help, I'm sure). I think it will help all of us find the threads that are most relevant to our individual goals and circumstances. Personally, I visit all the sub forums, but providing buckets for different subject areas provides advantages in other ways, as well.

Clara

[rocketmelon]

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[Lotus]

Ps. What do think of Eve's restructuring?, (of course I like it, no bias here, lol), honestly once you get the hang of it, it's pretty seamless.

L

I think it's a huge improvement, Lotus. I was pleased to see what Eve has done (with your help, I'm sure). I think it will help all of us find the threads that are most relevant to our individual goals and circumstances. Personally, I visit all the sub forums, but providing buckets for different subject areas provides advantages in other ways, as well.

Clara

Awesome, that was all Eve on the restructure, I did ask for her advice and also to please step in and address the situation, she deserves so much credit on having such a beautiful place that we all enjoy. (Sorry, just had to get that out there).

[Lotus]

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Thanks rocket, boobolgy! (I like that, lol) I'd like to become a boobolgist!, if such a thing exists!.

[Lotus]

Wow. My head swims. Or does the breast stroke.

Isn't it true that there are adverse health effect of high levels of DHT and estradiol? If so, are these not risk factors for the aromatase approach?

Inhibiting the enzyme 5 alpha reductase prevents the conversion to DHT, and the Aromatase enzyme converts free Testosterone to E2. Scientists are using the enzymes of 5-ar and aromatase as inhibitors to fight cancer.

Novel aromatase and 5 alpha-reductase inhibitors.
http://www.ncbi.nlm.nih.gov/pubmed/8043491

Risks and benefits of aromatase inhibitors in postmenopausal breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/10514021

• So the idea of using these enzymes for the benefit of breast growth isn't actually novel because your using them whether it's realized or not.
  

• Aromatase activity has not only been demonstrated in gonads and placenta but also in brain [6], fat tissue [7,8], muscle [9], hair [10], bone [11] and vascular tissue [12].
  

• Estradiol is the most potent estrogen produced in the body. It is synthesized from testosterone or estrone via aromatase or 17β-hydroxysteroid dehydrogenase, respectively.
  

• The total estradiol production rate in the human male has been estimated to be 35-45 μg (0.130-0.165 μmol) per day, of which approximately 20% is directly produced by the testes [13,14]. Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens [15].
  

• The mean estradiol plasma concentration in men is only about 1/200 of the mean plasma testosterone concentration [16] and is comparable to estradiol levels found in women in the early follicular phase of the menstrual cycle.
  

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143915/

_________________________________________________

Testosterone can bind directly to androgen receptors (ARs) or can be aromatized to estradiol (E2), acting on estrogen receptors (ERs), or reduced to dihydrotestosterone (DHT), acting on ARs.

• These metabolites (E2 and DHT) play crucial roles in the organism, mediating many functions such as cognition, reproduction, feeding, muscle, blood and brain metabolism.
  

• Thus modulation of the enzymes 5-alpha reductase and aromatase has to be considered an important gateway to these functions. The former plays an important role in testosterone conversion to DHT in androgen-dependent tissue, the latter in T aromatization to E2.
  

Aromatase

• There's an enzyme in the bodies of both men and women called aromatase. Its primary action is to produce female sex hormones, or estrogens. It produces them from male sex hormones (androgens) such as testosterone and their precursors.
  

• Aromatase also converts androstenedione (a sex hormone precursor) to the female hormone estrone, another estrogen, although weaker than estradiol.
  

• If you increase the activity of aromatase, you can increase levels of female sex hormones (estradiol, estrone).
  

• If you decrease the activity of aromatase, you can decrease levels of female sex hormones, while increasing relative levels of male sex hormones, e.g. testosterone.
  

• Men's bodies normally contain some level of estrogens, in addition to testosterone and their kind. Likewise, women's bodies contain some level of male androgens including testosterone.
  

• The ratio of male-to-female hormones contributes to our masculinity or femininity. Aromatase is one chemical that can tweak that ratio. It operates the same in both men and women, although an array of compounds can affect its activity.
  

________________________________________________________________

Testosterone-has two metabolites that pose potential problems for aging males and also for bodybuilders and athletes. One is estradiol (testosterone is converted to estradiol by the enzyme aromatase) and the other is dihydrotestosterone (DHT) (testosterone is converted to DHT by the enzyme 5-alpha reductase). As men age, there is a dramatic decrease in testosterone production, but without a corresponding decrease in the production of estradiol and DHT. Even though testosterone levels have plummeted, the aromatization of testosterone to estradiol is maintained, or even accelerated, and more testosterone is also being aromatized in fatty tissues. This creates excess levels of estradiol and, as a consequence, a blood level ratio of testosterone to estradiol that continues to decline, tipping the scale in balance of an estradiol-dominant environment.

[rocketmelon]

Wow. My head swims. Or does the breast stroke.

Isn't it true that there are adverse health effect of high levels of DHT and estradiol? If so, are these not risk factors for the aromatase approach?

Inhibiting the enzyme 5 alpha reductase prevents the conversion to DHT, and the Aromatase enzyme converts free Testosterone to E2. Scientists are using the enzymes of 5-ar and aromatase as inhibitors to fight cancer.

Novel aromatase and 5 alpha-reductase inhibitors.
http://www.ncbi.nlm.nih.gov/pubmed/8043491

Risks and benefits of aromatase inhibitors in postmenopausal breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/10514021

• So the idea of using these enzymes for the benefit of breast growth isn't actually novel because your using them whether it's realized or not.
  

• Aromatase activity has not only been demonstrated in gonads and placenta but also in brain [6], fat tissue [7,8], muscle [9], hair [10], bone [11] and vascular tissue [12].
  

• Estradiol is the most potent estrogen produced in the body. It is synthesized from testosterone or estrone via aromatase or 17β-hydroxysteroid dehydrogenase, respectively.
  

• The total estradiol production rate in the human male has been estimated to be 35-45 μg (0.130-0.165 μmol) per day, of which approximately 20% is directly produced by the testes [13,14]. Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens [15].
  

• The mean estradiol plasma concentration in men is only about 1/200 of the mean plasma testosterone concentration [16] and is comparable to estradiol levels found in women in the early follicular phase of the menstrual cycle.
  

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143915/

_________________________________________________

Testosterone can bind directly to androgen receptors (ARs) or can be aromatized to estradiol (E2), acting on estrogen receptors (ERs), or reduced to dihydrotestosterone (DHT), acting on ARs.

• These metabolites (E2 and DHT) play crucial roles in the organism, mediating many functions such as cognition, reproduction, feeding, muscle, blood and brain metabolism.
  

• Thus modulation of the enzymes 5-alpha reductase and aromatase has to be considered an important gateway to these functions. The former plays an important role in testosterone conversion to DHT in androgen-dependent tissue, the latter in T aromatization to E2.
  

Aromatase

• There's an enzyme in the bodies of both men and women called aromatase. Its primary action is to produce female sex hormones, or estrogens. It produces them from male sex hormones (androgens) such as testosterone and their precursors.
  

• Aromatase also converts androstenedione (a sex hormone precursor) to the female hormone estrone, another estrogen, although weaker than estradiol.
  

• If you increase the activity of aromatase, you can increase levels of female sex hormones (estradiol, estrone).
  

• If you decrease the activity of aromatase, you can decrease levels of female sex hormones, while increasing relative levels of male sex hormones, e.g. testosterone.
  

• Men's bodies normally contain some level of estrogens, in addition to testosterone and their kind. Likewise, women's bodies contain some level of male androgens including testosterone.
  

• The ratio of male-to-female hormones contributes to our masculinity or femininity. Aromatase is one chemical that can tweak that ratio. It operates the same in both men and women, although an array of compounds can affect its activity.
  

________________________________________________________________

Testosterone-has two metabolites that pose potential problems for aging males and also for bodybuilders and athletes. One is estradiol (testosterone is converted to estradiol by the enzyme aromatase) and the other is dihydrotestosterone (DHT) (testosterone is converted to DHT by the enzyme 5-alpha reductase). As men age, there is a dramatic decrease in testosterone production, but without a corresponding decrease in the production of estradiol and DHT. Even though testosterone levels have plummeted, the aromatization of testosterone to estradiol is maintained, or even accelerated, and more testosterone is also being aromatized in fatty tissues. This creates excess levels of estradiol and, as a consequence, a blood level ratio of testosterone to estradiol that continues to decline, tipping the scale in balance of an estradiol-dominant environment.

I really wanted to ask this !!! cause you duh expert ^_^
somebody on this forum...think it was bubblebra took T herbs to get converted to E ..she had really cool growth too !!!!!like think 7inch is in a year or something
I was wondering .......do you think that would be a good idea?
like if you took a small mg with white peony root? for example mucuna pruriens ....it's good for growth hormones ! .....more free T more estro?
more variety of estrogen from different sources ...like plant estrogen..and then plant T turned into real body E
I really wanted to know .......theres different types of estrogen..is the one created by T different ? .......I've heard also women take T sometimes to regulate their cycle .....do you think this is also a good way to keep in balance...or not a good idea ?


thanx =DD

[Dynseli]

you didn't ask me, but that sounds like a good idea. Possibly avoid it during ovulation, until it is known what that does to LH and FSH. At other times of the cycle, it may take trial and error to find the right ratio. Start off slowly. Add red reishi to counter any DHT that may be produced. If the effects start wearing down, cycle a different hormonal herb, or use massage rather than increase dosage.