30-12-2018, 02:30 AM
So this is the mystery in whats involved in PM, the following enzymes below are what catalyzes the metabolism of PM. Imo PM triggers insulin, which spikes the hunger hormone, and oh btw when insulin spikes it also triggers ANDROGENS.
Taking Calcium (which the manufacturer wants you to use with PM) helps trigger a cascade of reaction inside the cell. What we discovered here was PM inhibits the parathyroid, which is why we feel bone pain, Calcium helps to protect Osteocytes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608212/
As estradiol did, deoxymiroestrol induced expression of CYP2B9 mRNA whereas those of CYP1A2 were suppressed.
CY2B9 mRNA induced testosterone in women
CYP1A2 - metabolizes polyunsaturated fatty acids into signaling molecules
HSD-17B2 suppressed (E2 and T pathway)
17β-HSD1 suppressed (E2 pathway)
3β-HSD suppressed (catalyzes all steroids)
CYP17 (Human 17,20-lyase) activity is stimulated 10-fold by CYB5
CYP19 mRNA (aromatase) slightly decreased by deoxymiroestrol
Loosely translated- PM slightly inhibits T, but....it also slighty inhibits aromatase, the key thing is that PM blocks out the bodys own natural estrogen. And lets face it, you don't want or need to have Estrogen hanging around in our metabolism, meaning the bad metabolite 16 alpha-hydroxyestrone (16 alpha-OHE1), which enhances breast cell growth.
Taking Calcium (which the manufacturer wants you to use with PM) helps trigger a cascade of reaction inside the cell. What we discovered here was PM inhibits the parathyroid, which is why we feel bone pain, Calcium helps to protect Osteocytes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608212/
As estradiol did, deoxymiroestrol induced expression of CYP2B9 mRNA whereas those of CYP1A2 were suppressed.
CY2B9 mRNA induced testosterone in women
CYP1A2 - metabolizes polyunsaturated fatty acids into signaling molecules
HSD-17B2 suppressed (E2 and T pathway)
17β-HSD1 suppressed (E2 pathway)
3β-HSD suppressed (catalyzes all steroids)
CYP17 (Human 17,20-lyase) activity is stimulated 10-fold by CYB5
CYP19 mRNA (aromatase) slightly decreased by deoxymiroestrol
Loosely translated- PM slightly inhibits T, but....it also slighty inhibits aromatase, the key thing is that PM blocks out the bodys own natural estrogen. And lets face it, you don't want or need to have Estrogen hanging around in our metabolism, meaning the bad metabolite 16 alpha-hydroxyestrone (16 alpha-OHE1), which enhances breast cell growth.