[Aly_DD]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554576/


A patient seemed to take PM and end up in ER with stomach ache but with more diagnosis and finding unexpected blood results, patient was questioned and patient revealed that they were taking PM. Abnormal levels of serum triglycerides 2,559 mg/dl (nl 40-150 mg/dL) and lipase 481U/L (nl 13-60 U/l) were detected.

Anyone who's had PM for a while and have done some blood work post that care to share their triglycerides and lipase levels? I'd like to gather more info on this.

Thank you!

[FLWXPX]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554576/


A patient seemed to take PM and end up in ER with stomach ache but with more diagnosis and finding unexpected blood results, patient was questioned and patient revealed that they were taking PM. Abnormal levels of serum triglycerides 2,559 mg/dl (nl 40-150 mg/dL) and lipase 481U/L (nl 13-60 U/l) were detected.

Anyone who's had PM for a while and have done some blood work post that care to share their triglycerides and lipase levels? I'd like to gather more info on this.

Thank you!

You know, ever since I found this site and started doing research on all this hormone stuff hoping to garner the same results as everyone here, I’ve been petrified of screwing around with my body.

The human body is an extremely fragile, yet extremely well lubricated and calibrated precision machine. Kinda like my precision Swiss skateboard bearings. Perfectly polished, perfectly oiled, perfectly balanced. To mess with the body is like playing Russian roulette. You may be just fine, he may be just fine, but the next person…big problem.

I’ve been in perfect health (knock on wood) my entire life. Even today at just shy of 46 years old I’m frequently reminded over and over how lucky I am to have such a high metabolism, I can eat anything I want and not gain an ounce and not wake up with any pains and don’t have to take any kind of medications on a daily basis and can run up and down the stairs of my third floor condo with grocery bags without stopping to catch my breath or give my knees a break and how I have a wonderful full head of hair and how I still look 25 and that I can still speed skate like I did in my teens. My male friends I grew up with can in NO WAY keep up with how active I STILL am today. I’ve been blessed for sure.

I’ve been thinking about starting on PM and WP since December, but I kept having second thoughts. Not because I’m not sure I want breasts, I really do, but because of stuff like this story. And then Aly_DD goes and posts this.

I think this is a sign that I should not put diesel in my gasoline engine just to “see what happens.” Having breasts will never be more important than my health. I’m out. Thank you Aly_DD.

[Beth14]

Triglycerides and lipids have to do with Cholesterol I believe.

[Lotus]

Nice find Aly, 

Too bad the study didn't publish the brand name of the PM, or the BMI of the patient. The following are some opinions I have. The patient stated they took 2 capsules of pm daily. The two capsules per day of PM (if the patient was being upfront) seems unlikely to elevate triglycerides 2,559 mg/dl (nl 40-150 mg/dL) the patient had at the time ED visits. 

The ED additionally found necrotizing pancreatitis. My question is did the patient use other supplements? or follow unhealthy eating habits?. Curious to know what the patients baseline triglyceride level was. PM is known to pack on the pounds. HRT was started after the hospital stay... with supervision. I've posted about how PM increases triglycerides by 15% on both BN forums. This patient had a family history of unspecified hyperlipidemia in the father. With that in mind (a family history of unspecified hyperlipidemia) it's best to seek out medical advice before starting PM. 

• Normal — Less than 150 milligrams per deciliter (mg/dL), or less than 1.7 millimoles per liter (mmol/L)
  
• Borderline high — 150 to 199 mg/dL (1.8 to 2.2 mmol/L)
  
• High — 200 to 499 mg/dL (2.3 to 5.6 mmol/L)
  
• Very high — 500 mg/dL or above (5.7 mmol/L or above)
  

(quoted by Mayo clinic)



Effects and safety of Pueraria mirifica on lipid profiles and biochemical markers of bone turnover rates in healthy postmenopausal women

Manonai, Jittima MD1; Chittacharoen, Apichart MD1; Udomsubpayakul, Umaporn MSc2; Theppisai, Hathai MD1; Theppisai, Urusa MD1

Author Information

Menopause 15(3):p 530-535, May 2008. | DOI: 10.1097/gme.0b013e31815c5fd8

Objective: 

To evaluate the effect of Pueraria mirifica on lipid profiles and biochemical markers of bone turnover rates in healthy postmenopausal women and to evaluate the safety of Pueraria mirifica on endometrium; breast tissue; and hematologic, hepatic, and renal systems.

Design: 

This was a randomized, double-blind, placebo-controlled study in a university hospital of healthy postmenopausal women aged 45 to 60 years old. Women were enrolled voluntarily and randomly received 20, 30, or 50 mg Pueraria mirifica in capsules or identical placebo once daily for 24 weeks. Outcome measures were lipid profiles, bone-specific alkaline phosphatase level, endometrial thickness, endometrial histology, breast ultrasonography, complete blood count, liver function test, and renal function test.

Results: 

After 24 weeks of treatment, 71 women were evaluated. Of the 71 women, 51 randomly received varying doses of Pueraria mirifica and 20 received placebo. Pueraria mirifica and placebo significantly increased triglyceride levels by 15% from baseline levels (P < 0.05). The Pueraria mirifica group showed a significant decrease in bone-specific alkaline phosphatase levels after 24 weeks of treatment compared with the placebo group; from 0.22 ± 0.18 U/L to 0.13 ± 0.01 U/L in the Pueraria mirifica group and from 0.20 ± 0.10 U/L to 0.20 ± 0.14 U/L in the placebo group. Endometrial thickness did not change after treatment in both groups (P > 0.05). No endometrial proliferation or hyperplasia was reported after 24 weeks of treatment in both groups. There were no significant differences in adverse effects on breast tissue, complete blood count, and liver and renal function tests between the Pueraria mirifica and placebo groups in this study.

Conclusion: 

Pueraria mirifica at a dose of 20, 30, and 50 mg/d for a 24-week period demonstrated an estrogen-like effect on bone turnover rate. Pueraria mirifica did not demonstrate an estrogen-like effect on endometrial thickness and endometrial histology. Mild adverse effects occurred after Pueraria mirifica and placebo treatment.

https://journals.lww.com/menopausejourna...id.22.aspx

Pueraria mirifica group showed a significant decrease in bone-specific alkaline phosphatase levels after 24 weeks of treatment compared with the placebo group; from 0.22 ± 0.18 U/L to 0.13 ± 0.01 U/L in the Pueraria mirifica group and from 0.20 ± 0.10 U/L to 0.20 ± 0.14 U/L in the placebo group



Given patient’s desire for partial transition, low dose transdermal estradiol 0.05 mg patch and spironolactone 50mg BID started. On above regimen, estradiol was 179 pg/mL and total testosterone suppressed at 72 ng/dL. The patient’s triglycerides remained <150 mg/dL with no further complications.

[Cagedmuscle213]

I wonder if there were any other health issues at play.

[Fierachick]

I wonder if they took the "safe and effective" and the doctors are blaming it on the PM?

[DruLactin]

I wonder if they took the "safe and effective" and the doctors are blaming it on the PM?

perhaps, but its not like the Poke has been known to give people necrotizing pancreatitis.

[Fierachick]

Unfortunately I know someone who is suffering from necrotizing pancreatitis because of the poke, 3 of them. That shot gives people different effects, different cancers, different side effects as it was designed to be a soft killer. I wouldn't blame PM in this situation but the doctors, since they believe the FDS and CDC, will blame the disease/disorder on anything but the poison shot. The medical community is run by big pharma, so we will never know the truth.

[BlackButterfly]

Only one report is very odd, with a batch/contamination/product issue I'd expect more reports of problems.

Five dead and more than 100 in hospital after taking health supplements in Japan | World News | Sky News

[Teddy]

Only one report is very odd, with a batch/contamination/product issue I'd expect more reports of problems.

Five dead and more than 100 in hospital after taking health supplements in Japan | World News | Sky News

I think this is such a poisoning which could happen in principle with any foodstuff in any country. Rare, but sometimes very dangerous. The exact reason for poisoning seems to be still unclear ("The exact cause of the deaths is still under investigation", says the news article).

I wouldn't draw too many conclusions this or that way based on so limited information. However, the risk of something like this is always present, and can be reduced (but never zeroed out) by rigorous quality controls. You can get poisoned by a supplement or even food from a reputable grocery store.

This producer might have a need to quality control improvements -  the final report will tell if it is so, or if this was sabotage or a freak accident.