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Starting Domperidone

#3

(13-01-2022, 01:40 AM)VergeOfDiscovery Wrote:  Never heard of it but the Wikipedia entry for this drug makes for a rather interesting read. Apparently, it's not allowed to be sold in the US even by prescription (risk of arrhythmias, especially in men).

The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). Domperidone moderately increases the volume of expressed breast milk in mothers of preterm babies where breast milk expression was inadequate, and appears to be safe for short-term use for this purpose.[18][19][20] In the United States, domperidone is not approved for this or any other use.

Due to D2 receptor blockade, domperidone causes hyperprolactinemia.[30] Hyperprolactinemia can suppress the secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus, in turn suppressing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and resulting in hypogonadism (low sex hormone (e.g., testosterone, estradiol) levels).[31] As such, male patients may experience low libido, erectile dysfunction, and impaired spermatogenesis.[31] Also in accordance with hyperprolactinemia, 10–15% of female patients have been reported to experience mammoplasia (breast enlargement), mastodynia (breast pain/tenderness), galactorrhea (inappropriate or excessive milk production/secretion), and amenorrhea (cessation of menstrual cycles) with domperidone treatment.[30] Gynecomastia has been reported in males treated with domperidone,[32] and galactorrhea could occur in males as well.[31]

https://en.wikipedia.org/wiki/Domperidone


I very much hope that mammoplasia just means breast enlargement and not harmful growths within the breasts.
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Messages In This Thread
Starting Domperidone - by Avign0n4090 - 12-01-2022, 09:19 PM
RE: Starting Domperidone - by VergeOfDiscovery - 13-01-2022, 01:40 AM
RE: Starting Domperidone - by DruLactin - 13-01-2022, 06:09 AM
RE: Starting Domperidone - by Avign0n4090 - 13-01-2022, 05:12 PM
RE: Starting Domperidone - by VergeOfDiscovery - 13-01-2022, 12:50 PM
RE: Starting Domperidone - by Avign0n4090 - 14-01-2022, 12:40 AM
RE: Starting Domperidone - by Avign0n4090 - 18-01-2022, 09:26 PM
RE: Starting Domperidone - by Avign0n4090 - 19-01-2022, 06:55 PM
RE: Starting Domperidone - by Avign0n4090 - 29-01-2022, 05:51 PM
RE: Starting Domperidone - by Avign0n4090 - 03-02-2022, 06:33 PM
RE: Starting Domperidone - by Avign0n4090 - 09-02-2022, 07:19 PM
RE: Starting Domperidone - by Beard’nBoobs - 06-05-2022, 09:21 PM
RE: Starting Domperidone - by Avign0n4090 - 07-05-2022, 03:26 PM



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