[HelloDiDi]

Very interesting topics have been raised about it, it is a pleasure to read it.
I have a question about people with blood clotting problems. Is this method of using PM safer for the circulatory system?

That's what we're hoping. Suppository and transdermal dosing of pharmaceutical hormones is claimed to produce a significantly lower likelihood of clots, although suppository dosing isn't as well-researched, simply because it's considered to be less favorable than the popular patch method. It would stand to reason that PM could be "more safely" taken using the suppository.

As I understand it (and I'm pretty dense), Lotus is saying that liver activation is required when taking PM, but suppositories ARE liver-activated. But she is stating that a slow-release fatty acid-based suppository is best. That's a bit of a drag, but it is what it is.

Stating the above for (hopeful) clarification.

For me, I either need to pursue the suppository route or take Rutin for blood thinning and take my chances...or discontinue use altogether.

Hi Nipply & Sylvia, (Nipply my friend, you're far from dense). 

Over the years I've seen about a dozen cases of DVT being reported from PM use (at BN), even 1 case is way too many. So why is this happening?, here's my take:

Systemic inflammation (stemming from oxidative stress) can lead to thrombosis. Some years ago we had a thread helping people make sense of their hormone test results. What I found was users of PM had higher white blood cell count, indicating inflammation. Too much estrogen stimuli can lead to DVT. I still see people talking about taking 3,000mg of PM. This is an unnecessary risk to one's health, no matter how healthy the individual is. In cis-women only 250mg (or even 100mg) is recommended because of how it extends their menstrual cycle...plus a few other things. 1,000 to 1,500 is all I'd personally take if I was still on PM. Obesity and lack of exercise can be another risk factor. 

From the study below progesterone was found to inhibit the action of thrombin by 10-15%. Personally speaking progesterone cream should be included on day one if you're taking PM...or BO. We need that extra protection from progesterone when starting NBE. I would suggest vitamin D3 as it helps to reduce inflammation lowering the risk of thrombosis...go with vitamin D3 w/organic olive oil. I take 10,000 iu. 

Nipply (or anyone else) chose the route that's best for you. This information is to provide you with some options to consider. I will be introducing a new Breast Growing plan soon that will be a lower risk option. Feel free to ask questions. 

Listed Science:

Chronic Stress Facilitates the Development of Deep Venous Thrombosis
https://www.hindawi.com/journals/omcl/2015/384535/


Progesterone metabolites rapidly stimulate calcium influx in human platelets by a src-dependent pathway
Peter F Blackmore. Steroids. 2008 Aug.

Abstract
The effects of several steroids and their metabolites were examined for their ability to rapidly alter intracellular free calcium ([Ca(2+)](i)) in the anucleate human platelet. Earlier studies suggested that steroids had direct and rapid non-genomic effects to alter platelet physiology. The rationale for performing this study was to investigate the signal transduction events being activated by steroids. Super-physiologic concentrations (1.0-10.0microM) of beta-estradiol and several estradiol metabolites and analogs potentiated (approximately twofold) the action of thrombin to elevate [Ca(2+)](i) in platelets, whereas 10.0microM progesterone inhibited the action of thrombin by 10-15%. Progesterone and beta-estradiol by themselves did not affect [Ca(2+)](i). Progesterone metabolites can achieve high blood concentrations. Some progesterone metabolites, particularly those in the beta-conformation, were potent stimulators of Ca(2+) influx and intracellular Ca(2+) mobilization in platelets. They activated phospholipase C because their ability to increase [Ca(2+)](i) was inhibited by the phospholipase C inhibitor U-73122. The ability of pregnanediol and collagen to increase [Ca(2+)](i) was inhibited by the src tyrosine kinase inhibitor PP1, whereas the actions of thrombin and thapsigargin to increase [Ca(2+)](i) were not affected by PP1. The effects of progesterone metabolites to increase [Ca(2+)](i) were observed with concentrations as low as 0.1microM. Pregnanolone synergized with thrombin to increase [Ca(2+)](i). It is hypothesized that human platelets possess receptors for progesterone metabolites. These receptors when stimulated will activate platelets by causing a rapid increase in [Ca(2+)](i). Pregnanolone, isopregnanediol and pregnanediol were the most effective stimulators of this newly identified src-dependent signal transduction system in platelets. Progesterone metabolites may regulate platelet aggregation and hence thrombosis in vivo.


The role of oxidative stress and antioxidants in male fertility
https://pubmed.ncbi.nlm.nih.gov/24578993/

Reading the stuff above makes me to rethink what I'm doing... Along with experience on how I feel after more than one cycle without taking breaks. I wish I understood all this better.