[Isabela]

There's a potential downside to this concept. As can read above, rectal administration means faster onset and shorter peak. Not sure how that factors into the way estrogen should be absorbed. Does this mean it would be better to "inject" a tiny amount several times a day? That would be unreasonable.

I'm hoping someone with more knowledge on the subject (or willing to do more research) chimes in. With all that being said, taking the supplement Rutin is reported to be effective in preventing clotting issues - and it's way way cheaper than the pharma alternatives.

Well, I guess building breast tissue means binding estrogen receptors in the breast. May be this has nothing to do with the estrogen peak in the bloodstream, besides all hormones are likely to be pulsating, may be being high estrogen all the time doesn't help.