07-08-2016, 10:33 PM
Apigenin
https://www.amazon.com/Swanson-Apigenin-50-90-Caps/dp/B001TEIJIQ/ref=pd_sim_121_5?ie=UTF8&dpID=516dELHaViL&dpSrc=sims&preST=_AC_UL160_SR160%2C160_&psc=1&refRID=285Y2AYTTX9E3JZ54EFN
https://en.wikipedia.org/wiki/Apigenin
"Apigenin shows second-order positive modulatory activity at GABAA receptors.....Through effects on cell signaling, inflammation, cell cycle, and protease production, apigenin has demonstrated effectiveness against a wide range of cancer types, while not showing toxicity to normal cells"
however, it inhibits : CYP2C9
CYP2C9 is an important cytochrome P450 enzyme with a major role in the oxidation of both xenobiotic and endogenous compounds. CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes (data only for antifungal). Some 100 therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin and other routinely prescribed drugs such as acenocoumarol, tolbutamide, losartan, glipizide, and some nonsteroidal anti-inflammatory drugs. By contrast, the known extrahepatic CYP2C9 often metabolizes important endogenous compound such as 5-hydroxytryptamine and, owing to its epoxygenase activity, various polyunsaturated fatty acids, converting these fatty acids to a wide range of biological active products
not sure what to make of this so far, but more research is needed.
https://www.amazon.com/Swanson-Apigenin-50-90-Caps/dp/B001TEIJIQ/ref=pd_sim_121_5?ie=UTF8&dpID=516dELHaViL&dpSrc=sims&preST=_AC_UL160_SR160%2C160_&psc=1&refRID=285Y2AYTTX9E3JZ54EFN
https://en.wikipedia.org/wiki/Apigenin
"Apigenin shows second-order positive modulatory activity at GABAA receptors.....Through effects on cell signaling, inflammation, cell cycle, and protease production, apigenin has demonstrated effectiveness against a wide range of cancer types, while not showing toxicity to normal cells"
however, it inhibits : CYP2C9
CYP2C9 is an important cytochrome P450 enzyme with a major role in the oxidation of both xenobiotic and endogenous compounds. CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes (data only for antifungal). Some 100 therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin and other routinely prescribed drugs such as acenocoumarol, tolbutamide, losartan, glipizide, and some nonsteroidal anti-inflammatory drugs. By contrast, the known extrahepatic CYP2C9 often metabolizes important endogenous compound such as 5-hydroxytryptamine and, owing to its epoxygenase activity, various polyunsaturated fatty acids, converting these fatty acids to a wide range of biological active products
not sure what to make of this so far, but more research is needed.