[tanysquirrel]

menthol
https://en.wikipedia.org/wiki/Menthol
Some studies show that menthol acts as GABAA receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons.[5] Menthol also shares anaesthetic properties similar to propofol, by modulating same sites of GABAA receptor.[6]
GABAA_receptor_positive_allosteric_modulator:
In pharmacology, GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system. Unlike GABAA receptor agonists, GABAA PAMs do not bind at the same active site as the γ-Aminobutyric acid (GABA) neurotransmitter molecule: PAMs affect the receptor by binding at a different site on the protein. This is called allosteric modulation

GABA is a major inhibitory neurotransmitter in the Central nervous system. Upon binding, it triggers the GABAA receptor to open its chloride channel to allow chlorine ions into the neuron, making the cell hyperpolarized and less likely to fire. GABAA PAMs bind to a different site and increase the effect of GABA by making the channel open more frequently or for longer when GABA binds. However, they do not have an effect if GABA or another agonist is not present.

In psychopharmacology, GABAA receptor PAMs used as drugs have mainly sedative and anxiolytic effects. Examples of GABAA PAMs include alcohol (ethanol), benzodiazepines such as diazepam (Valium) and alprazolam (Xanax), Z-drugs such as zolpidem (Ambien), and the barbiturate drugs.

Biosynthesis of Neurosteroids[edit]

Neurosteroids are synthesized in the central nervous system (CNS) and the peripheral nervous system (PNS) from cholesterol and steroidal precursors that are imported from the peripheral sources. These sources include 3β-hydroxy-Δ5 derivatives, such as pregnenolone (PREG) and dehydroepiandrosterone (DHEA), their sulfates, and reduced metabolites such as the tetrahydro derivative of progesterone 3α-hydroxy-5α-pregnane-20-one (3α,5α-THPROG). After the local synthesis or from metabolism of adrenal of gonadal steroids many neurosteroids accumulate in the brain.[26][27]

interesting, so in theory, since Menthol absorbs alcohol trandermaly, then perhaps the Bovine ovary Vodka , or even a PM lotion or cream will accelerate in effect as theorized in the GABAA PAMs...