[tanysquirrel]

STUDY MENTHOL ON TRANSDERMAL ABSORPTION OF KETOCONAZOLE

menthol increases absorbtion rate of ketoconazole through skin.
http://en.cnki.com.cn/Article_en/CJFDTOT...001013.htm

OBJECTIVE:To observe the effects of menthol affecting the transdermal anount of Ketoconazole.METHODS:A simple cell was used as experiment apparatus.The Ketoconazole concentration was determined by multi wavelength areal integral UV spectrophotometry.RESULTS:The result showed that menthol helped enhance the skin permeation of Ketoconazole significantly(P0 01).At 3% menthol,the transdermal absorption rate of Ketoconazole in 24 hours increased by about 2.16 time.CONCLUSION:Menthol was able to enhance the transdermal absorption of Ketoconazole.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401672/
The present work focused on the formulation of KTZ transfersomes and the effect of natural permeation enhancers such as Eucalyptus oil, Turpentine oil, and Peppermint oil on the prepared KTZ transfersomes. Developments in the transdermal delivery of drugs offer a potential solution to improvement in the penetration of antifungal agents into the skin. One such approach has been the application of essential oils, such as eucalyptus oil, Peppermint oil, and Turpentine oil.[5] Eucalyptus oil is an effective skin penetration enhancer and it contains 1,8-cineole, a monoterpene cyclic ether which can enhance penetration of both lipophilic and hydrophilic compounds.[6–9] Turpentine oil and Peppermint oil also acts as a penetration enhancer. They increase the penetration of drugs when applied on the skin to give a faster onset of action. Here, an attempt has been made to incorporate both the mechanisms of transfersomes and permeation enhancers.

http://www.jdsjournal.com/article/S0923-...0/fulltext
Reversal of androgenetic alopecia by topical ketoconzole: Relevance of anti-androgenic activity
Ketoconazole (KCZ), an imidazole anti-fungal agent, is known to be effective for the treatment of seborrheic dermatitis and dandruff. In addition, 2% KCZ shampoo was found to improve hair density and the size and proportion of anagen follicles in androgenetic alopecia (AGA) [1] and, in combination with finasteride, to have an additive effect for AGA [2]. Recently, it has been reported that topical application of KCZ stimulates hair growth in C3H/HeN mice [3]. However, whether topical KCZ is effective enough to improve the clinical appearance of AGA is not yet clear.


wonder if menthol will also enhance the absorbtion of Bovine Ovary Vodka? ..hmmm