[tanysquirrel]

hops

contains: 8-prenylnaringenin
https://en.wikipedia.org/wiki/8-Prenylnaringenin

is a prenylflavonoid phytoestrogen. It is reported to be the most estrogenic phytoestrogen known.[1] The compound is equipotent at ERα and ERβ,[2] and acts as a full agonist of ERα.[3] Its effects are similar to those of estradiol, but it is considerably less potent in comparison.

8-PN is found in hops (Humulus lupulus) and in beer, and is responsible for the estrogenic effects of the former.[2][4] It can be produced from isoxanthohumol in fungal cells cultures,[5] and by flora in the human intestine.

Estrogenic[edit]

8-PN was shown to preserve bone density[1] and has been demonstrated to reduce hot flashes.[1][8] 8-PN also induces the secretion of prolactin, and increases other estrogenic responses.[9] The compound binds to and activates ERα more times than it does to ERβ.[1][2][10]

This prenylflavanoid has drawn interest in the study of hormone replacement therapy, and it is comparable to selective estrogen-receptor modulators.[11][12]

In an in vivo study, 8-PN has activated proliferation of mammary cells.[9] At the concentration found in beer, it is unlikely to have an estrogenic effect in breast tissue.[13] Prenylflavonoids from hops, namely 8-PN, are common in herbal breast enlargement preparations.[14]

Similarly to other estrogens, 8-PN induces the expression of the progesterone receptor in various tissues

very interesting.. more research needed.