15-05-2016, 10:50 PM
Gper, creeper, where did ya get those peepers....
interesting ,not only ERa and ERb, but also. GPER.
G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 (GPR30),
https://en.wikipedia.org/wiki/GPER
"GPER is expressed in the breasts, and activation by estradiol produces cell proliferation in both normal and malignant breast epithelial tissue.[13][14] However, GPER knockout mice show no overt mammary phenotype, unlike ERα knockout mice, but similarly to ERβ knockout mice.[13] This indicates that although GPER and ERβ play a modulatory role in breast development, ERα is the main receptor responsible for estrogen-mediated breast tissue growth.[13] GPER is expressed in germ cells and has been found to be essential for male fertility, specifically, in spermatogenesis.[15][16][17][18] GPER has been found to modulate gonadotropin-releasing hormone (GnRH) secretion in the hypothalamic-pituitary-gonadal (HPG) axis.["
symbiotic to ERa?
more research needed.
interesting ,not only ERa and ERb, but also. GPER.
G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 (GPR30),
https://en.wikipedia.org/wiki/GPER
"GPER is expressed in the breasts, and activation by estradiol produces cell proliferation in both normal and malignant breast epithelial tissue.[13][14] However, GPER knockout mice show no overt mammary phenotype, unlike ERα knockout mice, but similarly to ERβ knockout mice.[13] This indicates that although GPER and ERβ play a modulatory role in breast development, ERα is the main receptor responsible for estrogen-mediated breast tissue growth.[13] GPER is expressed in germ cells and has been found to be essential for male fertility, specifically, in spermatogenesis.[15][16][17][18] GPER has been found to modulate gonadotropin-releasing hormone (GnRH) secretion in the hypothalamic-pituitary-gonadal (HPG) axis.["
symbiotic to ERa?
more research needed.