[Lotus]

I can only relate what my doctor said after prescribing Spiro for my blood pressure .  She suggested taking it morning or no later than noon.

She explained that spiro aggravates my gyne by nearly stopping DHT.  And that by keeping on a regular regimen, my body would adjust and slowly slow DHT to almost negligible amounts.  And boosting what ever Estrogen my body already made on it's own.

Now granted, she is no Endo, but I think it's the easiest explanation for a novice to understand...

I would think that since herbs are far weaker, that what Lotus said is very true.  It's just not strong enough, nor does it last long enough to put a stop to a fully functioning Endo system.  Spiro, I suspect, has a far greater chance.

Trying to block DHT is like playing "whack a mole"..........it finds a pathways for docking (binding). I say we go further upstream before DHT can find certain pathways.

I've found the answer if anyone is interested in (near) complete androgen suppression.