[Lotus]

We've only had one thread on half life, time to unlock NBE (hrt too) and explore the timing of when and how much to take:

Half-life: The period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.
---------------------------

The half-life of steroid hormone receptors ranges from 2 to 4 hours for ERα, 4 hours for AR, 7 to 10 hours for PR, and 19 hours for GR. The relatively long half-life of the steroid hormone receptors strongly suggests that the receptor proteins are recycled before eventual degradation.

I'd recommend taking (oral nbe between 3-4 times per day at lesser dosages). This way your delivery of what you use matches the half life. Big note here, taking high doses of PM, E2 and FENUGREEK lowers the number of available receptors, which will kill any program (see added science).

Steroid hormones generally autoregulate their receptor levels. Desensitization or downregulation of receptor numbers, measured by decreased ligand binding capacity, occurs in response to exposure to high levels of ligand and involves the reduction in receptor mRNA levels, decreasing the number of available receptors. The receptor gene may be negatively regulated by the hormonal ligand itself through its receptor protein interacting with specific HREs in the gene. Upregulation or self-priming may occur in an analogous fashion. Steroid hormones can regulate receptor levels for other hormones (e.g. E2 increases PR levels in estrogen-responsive tissues). Progesterone can downregulate its own receptors, as well as ERα and ERβ. This increase or decrease in receptor levels in homologous or heterologous regulation can be caused by alterations in receptor gene transcription or decay rates for receptor mRNA or protein.

 So imo take what we know about NBE and throw out the play book. Meaning a confusion exists (well imo) of when and how long to take supplements that will be effective. It also explains how receptor recycling (degradation) and not just steroid receptors gets excreted and recycled again and again. What this means is (and I'll try to explain so all can follow), that taking supplements in shorter (and less) bursts to follow the steroid half life's (this means receptor control too) cycle. 

Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol
CONCLUSION: 
Sublingual administration of micronized 17 beta-estradiol results in a rapid, burst-like absorption into the systemic circulation, yielding high E2 levels that fall rapidly over the first 6 hours.
http://www.ncbi.nlm.nih.gov/pubmed/9052581

___________________________

The apparent half-life of E2 after discontinuing a transdermal E2 patch is 2.7 h or 161 min.

___________________________

Puerarin (after 7.5g/kg water extract of the decoction) were a half-life of 46.9 minutes (β-Half life of 925.7min) and AUC of 790.3μ min/mL; a Cmax of 1.41ug/mL (3.39umol/L) and a Tmax of 18.5 minutes; suggesting rapid absorption.

__________________________

Elimination half-life of endogenous testosterone is 10 to 100 minutes and is dependent on the amount of free testosterone in the plasma. Exogenous testosterone, such as testosterone cypionate (when injected intramuscularly) has a half-life of approximately eight days.

____________________________

Why increasing the dosage doesn't always work

Negative feedback occurs when the result of a process influences the operation of the process itself in such a way as to reduce changes. Feedback can produce stability and reduce the effect of fluctuations. Negative feedback loops in which just the right amount of correction is applied in the most timely manner can be very stable, accurate, and responsive. In other words, do you remember your body made changes when starting PM or E2?Some good changes did occur, however, the changes in testosterone made your testicles feel like it was going to explode. 

Negative feedback loops have been compared to a thermostatically controlled temperature in a house, where the internal temperature is monitored by a temperature-sensitive gauge in the thermostat. If it is cold outside, eventually the internal temperature of the house drops, as cold air seeps in through the walls. When the temperature drops below the point at which the thermostat is set, the thermostat turns on the furnace. As the temperature within the house rises, the thermostat again senses this change and turns off the furnace when the internal temperature reaches the pre-set point.

Negative feedback loops require a receptor, a control center, and an effector. A receptor is the structure that monitors internal conditions. For instance, the human body has receptors in the blood vessels that monitor the pH of the blood. The blood vessels contain receptors that measure the resistance of blood flow against the vessel walls, thus monitoring blood pressure. Receptors sense changes in function and initiate the body's homeostatic response. Cycling NBE or NBE will diminish blood levels of PM and ESTRADIOL, and you'll feel like crap because you've interrupted the steady state of delivery from the former and latter. CYCLING NBE or HRT ISN'T NECESSARY,  TO RECAP, YOU'LL REDUCE YOUR BLOOD LEVELS OF NBE/HRT by cycling, upsetting the apple cart so to speak.  

The goal (when doing NBE/HRT) is keeping a steady state of PM/E2... even for 

Read more: Homeostasis - Negative feedback - Body, Blood, Internal, and Conditions - JRank Articles http://science.jrank.org/pages/3365/Home...z34AWy8WWP

____________________________________________________________

Cycling supplements isn't for NBE/HRT. Once your body makes the adjustments to get back to homeostasis (from the negative feedback loop of starting NBE/HRT) you're body will fight you to keep at your current NBE/HRT levels.