16-11-2022, 11:30 PM
Here's a blast from the past with some new updates, hope you enjoy. More science fun to follow.
(15-05-2019, 03:44 AM)Lotus Wrote: I've written about how by reducing DHT it up-regulates estrogen receptors in the past. E1 plays a role in peripheral aromatization of androstenedione (that's through the A1 pathway), but...E2 is the strongest form of estrogen.
From experience I've found that hyperinsulinemia (too much glucose) has a negative impact on breast growth. Evidence suggests this is the case in women with PCOS, which PCOS is hyperandrogenism....(a negative impact for breast growth) amongst stress and inflammation too a driving of PCOS, and stress decreases aromatase in ovarian cells, so...what does that tell yah.
E2 and E1 can be converted into each other (known as crosstalk) and both can be inactivated via hydroxylation and conjugation. E2 demonstrates 1.25 to 5 times the biological potency of E1. E2 circulates at 1.5 to 4 times the concentration of E1 in premenopausal, nonpregnant women.
(Mayo clinic).
Glucocorticoids (which are present in breast tissue) increase androgen inactivation, I see reishi increases glucocorticoids to a degree, and thereby inactivating androgens. Also, androgens, but not estrogens increase beta adrenergic receptors (think of adrenergic receptors as neurotransmitters to CAMP, or aromatase production)while decreasing alpha adrenergic receptors- which results in increased levels of epinephrine/ norepinephrine due to lack of alpha-2 receptor negative feedback and decreased fat accumulation. In other words, epinephrine/ norepinephrine then act on lipolysis-inducing beta receptors.
So, one can say that using beta blockers help with breast growth (by the above pathway) to liberate lipolysis for a thermogenic response. And from my experience this creates fullness in breast tissue (it did for me).
And here's how:.
β-2 AR (which stands for beta 2 alpha adrenergic receptors) activation increases the intracellular cyclic AMP levels that activate protein kinase A, which in turn promotes activation of hormone-sensitive lipase that catalyzes the rate limiting step in lipolysis, and lipolysis is the breakdown of fats. And what happens when you break down stored fat?...you release ESTROGEN. See you, it all starts to make sense. This stored estrogen once released is now usable for synthesis, not only as energy but for building breast tissue. Though this is where MSM helps this process because of a particular pathway MSM utilizes I've described many times over in the past which mostly gets ignored so I won't repeat it here lol. Needless to say it promotes aromatase.