[Lotus]

thankyou Lotus, thats an interesting article x

You're welcome Lady Charlotte 


Short-Term and Long-Term Histologic Effects of Castration and Estrogen Treatment on Breast Tissue of 14 Male-to-Female Transsexuals in Comparison With Two Chemically Castrated Men
https://journals.lww.com/ajsp/Fulltext/2000/01000/Short_Term_and_Long_Term_Histologic_Effects_of.9.aspx

When searching for progesterone research years ago I came across this (albeit small cohort) study which I shared with BN. Biopsy specimens of breast tissue chemically castrated male-to-female transsexuals was used for
histopathologic research (e.g) cancer, gynecomastia, subcutaneous mastectomy, prostatic carcinoma, breast augmentation, etc. 

Quote from the study:
Conclusion 
 A slight increase in the plasma estrogen-to-androgen ratio usually does not induce acinar and lobular formation in the male breast. In men treated with non progestative antiandrogens for prostate cancer, only moderate acinar and lobular formation occurs. Only in male-to-female transsexuals in whom progestative chemical castration is combined with feminizing estrogen therapy will full acini and lobular formation occur. Hence, combined progestative antiandrogens and estrogens is necessary for the genetically male breast to mimic the natural histology of the female breast. Orchidectomy does not contribute to the development of acini and lobules. Metaplasia may occur in breasts of male-to-female transsexuals, but so far, only four cases of breast cancer in male-to-female transsexuals have been documented. Provided that they are treated conservatively with estrogens, it is suggested that male-to-female transsexuals have the same annual risk of breast malignancy as do genetic females.
End quote.
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Worth noting is the use of cyproterone in this study, which is a progestative drug as it is mentioned, which stimulates the formation of acini and lobules in breast tissues. Acini in breast tissue represents milk ducts and is part of the TEB (Terminal End Bud) which are several hundred per cell, lobules are also milk ducts.

The study doesn't mention specifically when progestative drugs were added to each program (unless I missed it). Aside from my own personal growth, I made my mind up on when to add progesterone, and also in part from research like this and others like it, but also in large part the fact estrogen and progesterone are released at the start of menstruation during puberty. 

" Combined progestative antiandrogens and estrogens is necessary for the genetically male breast to mimic the natural histology of the female breast "

Or, HRT program:
Micronized progesterone, E2 and an AA (like bicalutamide) MSM, Vitamin D3, melatonin, as a base program with other options below:


Or, NBE program:
PM, progesterone cream, Red Reishi, MSM, Vitamin D3, melatonin, as a base program listed on page one of this thread.


Cayenne/Ginseng Tincture

 Ginseng initiates the cAMP/PKA/CREB pathway which is a major breast growing pathway.The ginsenosides in ginseng inhibits glucocorticoids, which is beneficial for breast growth, though in the beginning of breast growth glucocorticoids are needed.

So you make a liquid tincture with these, meaning with 6-8oz of water, squeeze in 1/2 of a lemon, (lemon are acidic outside the body but alkalizing in the body...plus it inhibits T) and cayenne liquid extract, aids in reducing stomach fat too. The cayenne has quite a few health benefits, like it's an appetite suppressant and initiates thermogenesis in fat cells, which is beneficial for breast growth, you'll find information on thermogenesis in this thread, type in thermogenesis, cayenne in the search option on the bottom on each page. I purchased cayenne extract on Amazon, I found one that's alcohol free and organic. Please discuss using Cayenne/Capsicum with your health care professional, it may not be right for everyone. The instructions on the extracts say to dilute the extract...this is very important. 

I've been cataloging research for years lol, recently I came across information on how TEB (Terminal End Buds) are created, other than what's been discussed in this thread this process is derived from TGF-alpha/EGF as being essential for the growth of breast buds (aka-terminal end buds). TGF stands for Transforming Growth Factor, and EGF for epidermal growth factor. Honestly it's exciting science