(28-01-2022, 08:10 AM)Lotus Wrote: Hi Alexis,Hello Lotus, thank you again for your precious research for all of us!
You're welcome, I'll definetly have more time next week for sure, I'm having back surgery (to make repairs) early next week. So if I make posts that are gibberish you'll know it's the pain meds talking.
There's a difference between USP progesterone and wild yam progesterone. USP progesterone is bioidentical (as in made by humans) as opposed to wild yam made in a lab. WY isn't progestative, apologies. Though in the absence of using estradiol it helps with aveolargenesis (ductal growth).
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Here's some research I put together based on science literature. Progesterone suppresses activation and crosstalk between PR (progesterone receptor) and prolactin/Stat5 signaling to inhibit milk protein gene expression. These changes are reflected in reduced activation of JAK2 and PAK1, resulting in downregulation of pSTAT5.
However, MSM stimulates the activation of the Jak2/STAT5 signaling pathway to help secrete milk protein. MSM also stimulates GH (growth hormone) induced activation of Jak2/STAT5b and prolactin production.
Why is this important?, progesterone downregulates the Jak2/STAT5 pathway that inhibits milk proteins and affect terminal end buds (TEB's which are the branch like structures that fill out breasts) growth and alveologenesis. Taking MSM helps to restore what progesterone destroys during its protein metabolism. We also learned progesterone is catabolic to protein expression in breast tissue. Now we can address this catabolism (breakdown of proteins) by adding amino acids to the mix...possibly tyrosine and proline to strengthen the protein loss. Or possibly consuming more protein in our diet.
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Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland
https://pubmed.ncbi.nlm.nih.gov/33282878/
Scribble promotes alveologenesis in the pregnant mammary gland for milk productionScribble promotes alveologenesis in the pregnant mammary gland for milk production
https://pubmed.ncbi.nlm.nih.gov/32213656/
Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells
https://pubmed.ncbi.nlm.nih.gov/19494234/
Jak2 Is an Essential Tyrosine Kinase Involved in Pregnancy-Mediated Development of Mammary Secretory Epithelium
https://academic.oup.com/mend/article/16...ogin=false
I wish you the best outcome from the surgery, especially for the recovery. I only once had surgery and it was devastating, i really hope the doctors will handle everything with care. <3
All clear about USP Progesterone and the Wild Yam one, thank you for the explanation. Unfortunately am still a little confused about the bottle am currently using, they use a tricky wording which makes it a little unclear, seems like USP bioidentical but they then put a paranthesis with wild yam in it. I directly share the picture of the ingredients on this post, i appreciate a lot to know what you think about this labelling.
This new update you wrote and shared here is surprisingly eye-opening. I did try MSM in the past for just a few days, i didn't like the taste and for a lack of privacy i got it thrown away. I thought i wasn't missing anything special because those only 3 days i tried it, but if the job of MSM is to cooperate with Progesterone Cream, then it means i really should give it another try! Since i already take Progesterone Cream with my program, it could only benefit from this!
About tyrosine and proline i'll think about it, seems like there are some capsules supplements on Amazon, which i could take at some point. Do you think they could be some reliable sources? and are they a priority addition into the program?
As always, thank you so much for the help and insight you give to us all, Lotus always giving hope and help <3