19-02-2021, 07:55 AM
Greetings,
I posted this study in 2015 to show the importance of having progesterone in your program. The takeaway here is that without progesterone while taking estradiol and anti-androgen breasts don't mature. Meaning the alveoli, breast ducts and breast buds don't develop to tanner stage 5 potential.
In another study an assay of human male hormone receptors in breast tissue found the following (and this in regards to each being equal to 100%, not the total of the three being @ 100%, follow?).
Breasts
Estrogen receptors @ 94%
Progesterone receptors @ 93%
Androgen receptors @ 57%
So, in human male testes we have the following productions:
Testes
Testosterone @ 85%
Estradiol @ 15%
Anti-androgens inhibit T/DHT between 30-90%. When T is lowered to 50ng/dL and below its considered chemical castration.
So this is how my thinking goes:
Use progesterone cream to reduce T/DHT in breast tissue.
And in the testes reduce that testosterone of 85% to 5 to 10% using an effective anti-androgen that inhibits @ 80%.
Simple, right?. I believe one could tweak these numbers to how they wish to proceed. Meaning some don't want breast development while others do. We just massage these numbers to create a small imbalance favoring feminization but no breast development, I would do that by just using progesterone cream on the breast...no PM (or estradiol) and an anti-androgen titrated to 45-50% or flip the script geared towards breast growth, and titrate even more for the full feminization.
I posted this study in 2015 to show the importance of having progesterone in your program. The takeaway here is that without progesterone while taking estradiol and anti-androgen breasts don't mature. Meaning the alveoli, breast ducts and breast buds don't develop to tanner stage 5 potential.
In another study an assay of human male hormone receptors in breast tissue found the following (and this in regards to each being equal to 100%, not the total of the three being @ 100%, follow?).
Breasts
Estrogen receptors @ 94%
Progesterone receptors @ 93%
Androgen receptors @ 57%
So, in human male testes we have the following productions:
Testes
Testosterone @ 85%
Estradiol @ 15%
Anti-androgens inhibit T/DHT between 30-90%. When T is lowered to 50ng/dL and below its considered chemical castration.
So this is how my thinking goes:
Use progesterone cream to reduce T/DHT in breast tissue.
And in the testes reduce that testosterone of 85% to 5 to 10% using an effective anti-androgen that inhibits @ 80%.
Simple, right?. I believe one could tweak these numbers to how they wish to proceed. Meaning some don't want breast development while others do. We just massage these numbers to create a small imbalance favoring feminization but no breast development, I would do that by just using progesterone cream on the breast...no PM (or estradiol) and an anti-androgen titrated to 45-50% or flip the script geared towards breast growth, and titrate even more for the full feminization.
(25-09-2015, 01:36 AM)Lotus Wrote: Short-term and long-term histologic effects of castration and estrogen treatment on breast tissue of 14 male-to-female transsexuals in comparison with two chemically castrated men.
Kanhai RC1, Hage JJ, van Diest PJ, Bloemena E, Mulder JW.
Author information
Abstract
The histologic changes induced in the mammary gland of male-to-female transsexuals have not yet been reported in the literature. We studied the histologic changes induced by chemical and surgical castration and estrogen therapy in the breasts of 14 such patients, with particular reference to acinar and lobular formation. To objectify the influence of cross-sex treatment, the histologic findings were compared with those in two men treated hormonally for prostate cancer. The slight increase in the plasma estrogen-to-androgen ratio seen in idiopathic gynecomastia usually does not induce acinar and lobular formation in the male breast. In men treated with nonprogestative antiandrogens for prostate cancer, only moderate acinar and lobular formation occurs. Only in male-to-female transsexuals in whom progestative chemical castration is combined with feminizing estrogen therapy will full acinar and lobular formation occur with hormonally stimulated nuclei and pseudolactational changes. Hence, combined progestative antiandrogens and estrogens are necessary for genetically male breast tissue to mimic the natural histology of the female breast. Orchidectomy does not contribute to this. Apocrine metaplasia may occur in breasts of male-to-female transsexuals, but so far, only four cases of breast cancer in male-to-female transsexuals have been documented.
Here's the full paper, or view the PDF as listed on the site.
http://journals.lww.com/ajsp/Fulltext/20..._of.9.aspx