31-01-2021, 03:05 AM
(30-01-2021, 06:05 AM)marshallenfj Wrote: Thanks for all the background information, Lotus! Very informative. And good to meet you too.
You're welcome.
(30-01-2021, 06:05 AM)marshallenfj Wrote: It's just Marshall btw, I was just getting into the myers-briggs personality types at the time I found this site, enfj is one of them. Both that and exploring whether feminization, which I've been into pretty much all my life, were part of a drive for better health and happiness.
Awesome. Marshall...I love that name.
(30-01-2021, 06:05 AM)marshallenfj Wrote: Yeah, you're definitely right about this not being without risks and the T-spikes when starting explains a lot of my experience. It was initially very encouraging because I felt started feeling really good - horny too - when I started so it felt right for me, but headaches, muscle cramps, and fatigue set in pretty quickly. That's why I've still been experimenting with what's right for me.
Well, now we know why this happens, it's just getting others the information.
(30-01-2021, 06:05 AM)marshallenfj Wrote: Sorry to pester you, but can you advise me in related question?no worries here.
(30-01-2021, 06:05 AM)marshallenfj Wrote: My goals are similar to Therasa's. I want curves, hips, and an ass more than breast development, though I understand that breasts develop first and long before other meaningful fat redistribution. I would also love a discreet, sensitive chest, and once I started getting some sensations in my chest, I've become more inclined to develop my breasts. It's wild to actually feel growing pains and sensitivity changes, but the negative health impacts, among personal factors, keep preventing me from making any real progress. I also want to experience general feminization mentally/emotionally to figure if out if I should continue. I'm 28 y/o, 6'5", ~245, ~29 BMI and don't want to risk permanent organ damage if this isn't for me.that's understandable.
(30-01-2021, 06:05 AM)marshallenfj Wrote: I've recently narrowed down the other daily supplements I like and was going to start another experiment regimen soon when I saw your post:
500-2000mg PM
2000-4000mg White peony
3-10g maca
Green tea replace coffee
Green tea is good, it inhibits 5 alpha reductase type I & II, meaning it'll inhibit DHT in hair, prostate and other target tissue.
(01-10-2020, 04:41 AM)Lotus Wrote:(05-01-2016, 11:09 PM)Lotus Wrote: I think we have an answer, Green Tea Extract- GTE inhibits prostate cancer by reducing the cell growth and blocks the androgen receptor. Green tea extract needs to be @ 60-80% in EGCG polyphenols though. The dosage needs to be determined, recommend use is 2-3 capsules per day, I'm thinking it's slightly more (4-5?) from what this study says. Would this eliminate the need for other anti-androgens?, possibly. Soooo- I see a good plan as follows: (though, it's up to you, it won't hurt my feelings).
1-pro-estrogen source
1-pro-aromatase
Green tea extract (imo 4-5 caps per day)
1-growth hormone source
Add the standard healthy fats, exercise, massage, pumping, etc.
Quote: Epigallocatechin-3-gallate EGCG, the major polyphenolic constituent present in green tea, imparts antiproliferative effects against both androgen-sensitive and androgen-insensitive human PCA cells, and this effect is mediated by deregulation in cell cycle and induction of apoptosis. GTE is a potent inhibitor of type 1 but not type 2 5α-reductase. (−)Epigallocatechin-3-gallate also inhibits accessory sex gland growth in the rat. These results suggest that certain tea gallates can regulate androgen action in target organs.
Quote: EGCG (green tea) acts as an antagonist of androgen function, similar to the pharmacological inhibitor Casodex, which was used as a control.
So what does this mean?,........it means green tea acts like a pro-pharma class of anti-androgens named Casodex, as in brand name Bicalutamide-aka, a pure antiandrogen used in the treatment of prostate cancer:
Bicalutamide
https://en.m.wikipedia.org/wiki/Casodex
Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer
The present study is one of the first few reports demonstrating the antiandrogenic action of a plant product and the first report showing the effect of EGCG, a naturally occurring polyphenol present in green tea, in inhibiting human prostate carcinoma cell growth. We have shown that EGCG effectively inhibits the transactivation functions and expression of AR by interfering with its stability as a result of decreased interdomain interaction (Fig. 5). We also showed that EGCG is a novel antagonisT signaling, which can block AR-regulated gene expression and cell growth in human PCa cells. We thus suggest that EGCG could be developed as a chemotherapeutic agent against hormone-refractory PCa.
http://www.fasebj.org/content/25/4/1198.full
4-5 cups of green tea per day is a bit much, 2 cups per day is reasonable. And btw, EGCG is antiviral.
(30-01-2021, 06:05 AM)marshallenfj Wrote: I tried to see palmetto but felt awful. I still want my energy and vitality, so my thinking is to have a relatively low dose of PM, no anti-androgen, and instead promote aromatase to develop rather than dropping T.
Saw palmetto didn't work for me either. In order for aromatase to work testosterone needs to be inhibited, and here Green Tea can inhibit DHT. It doesn't reduce total T, it just blocks the receptors, thus Total T isn't really reduced because nearly all of T isn't really bioactive except 3-5%...and this small fraction is what's known as Free T. Estradiol works the very same way T works, meaning only 3-5% free estradiol is bioactive. This (E2-.estradiol) scenario is rarely talked about, but exists.
(30-01-2021, 06:05 AM)marshallenfj Wrote: At a passing glance, does this make sense? Am I missing something or doing something stupid? Finally, would this kind of regimen combine well with the low-risk one you posted? I'd assume it would.
It does make sense. The EGCG in green tea (per the study) used less than 1mg of EGCG (aka Epigallocatechin Gallate). I've used decaf green tea with 98% EGCG polyphenols, so I know it works. So, if inhibit DHT the better chance of feminizing. You can always add a pro-aromatase to help the conversion of T to E. I can give you a list of pro-aromatase items. And there's one final approach to all this is just increasing SHBG (sex hormone binding globulin), that's right, SHBG has the potential to become a estrogen amplifier. I'm going to lay all that out, plus a few other exciting things asap. Oh, what meds do you take?.
(30-01-2021, 06:05 AM)marshallenfj Wrote: Thanks again for all the info you've provided already, I also previously have been reading your older posters about what everything is/does. And sorry for asking for a review of my personal stuff. If this type of thing/goals have been discussed before, can you just point me in that direction?.
Cheers
My pleasure, that's awesome, you'll never know what you'll find in this threads archive unless you read it.