01-10-2020, 04:20 AM
(24-09-2020, 07:51 AM)Trouble with Nibbles Wrote: So finally getting to my question about it. Given all this, can green tea alone affect significant feminization? We know what it does to DHT also.
As always, thanks!
Hi TWN,
Hard to say with any certainty that green tea by itself can feminize. If you incorporated a PDE4 inhibitor it may peak my curiosity to run a cycle or two. But essentially inhibiting PDE4 boosts cAMP...which stimulates that estrogen pathway. Viagra is a PDE5 inhibitor, but doesn't stimulate cAMP like PDE4 does. PDE enzymes are classified into 12 families (aka as a superfamily of enzymes).
For example,
Quercetin (in green tea) is pro-aromatase, in the magnitude of 3-4 fold. It (quercetin) does this by stimulating Adenylyl Cyclase via the cAMP/PKA creb pathway, which I've explained in detail that this pathway an effective estrogen pathway, but let's consider cAMP/PKA creb pathway to be the best feminizing pathway to date.
However, this is what we know about Adenylyl Cyclase, it catalyzes the conversion of ATP (adenosine triphosphate, aka cellular energy source) into the second messenger known as cAMP(cyclic adenosine monophosphate). And this increase in estrogen-activates gene transcription...in other words new breast growth.