[Lotus]

I have been reading that bicalutimide 50mg will block T receptors, thus more free T is available for aromatase. The T levels increase, but no receptors. Whereas spiro simply blocks T. Dr Will Powers in MI is using this. Have you heard of this or have a comment? I do not think there is a lot of history or records on this.

Hi Sioctober,

Apologies for the late response. I've posted many times in the past about having more free T available potentially creates a cascade of estrogen. The only problem is finding what works for the conversion, meaning everyone is different because of the varying degrees of individual metabolism. Now, I believe there's things in the NBE medicine cabinet to achieve the conversion of aromatase. The top in my mind is using second messengers, check the FAQ aromatase section for examples, personally?...I prefer glycosides. I'll add the following info below as an example though.

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Remember-only hormones that detach from SHBG and Albumin are considered in the FREE state, about 2-5%, that's FREE testosterone and FREE estradiol, which will be available the bind with receptors and induce growth.

* Certain metabolic pathway that has direct impact on breast growth.

* For instance, there's a specific agonist for a nongenomic pathway of sex steroid receptors that stimulates breast growth.

* Ginsenosides are a class of steroid glycosides, and triterpene saponins. Brilliant huh?...

cAMP-dependent signaling pathways (cyclic adenosine monophosphat).
COX2 inhibitors (PGE2), problematic
protein kinase A (PKA)
Free fatty acids

* Aromatase expression is switched to promoters I.3 and II which are transactivated by protein kinase A (PKA) and cAMP-dependent signaling pathways.

These are promoters genes for aromatase.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142499/

* History of high blood pressure, PCOS, HIGH cortisol, diabetes...latest blood work, any other complications, current meds and herbals.

* Please read this study.
Pharmacology of ginsenosides: a literature review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893180/

(Especially this section in the study)
Ginsenosides are agonists to steroidal receptors

* Cortisol + glucocorticoids + cAMP = aromatase.

Now that's just the starting point, you'll also need a balanced gut PH, proper diet/exercise, and balanced hormones. 

These studies listed below sets forth the ground work that taking the aromatase we have in our system and combining it with a cAMP (second messenger....which is panax ginseng) and a glucocorticoid (vitamin D3) reaches the breast growth pathway in no uncertain terms. I'm not concerned all the low bioavailability of the Ginsenoside's in ginseng, you don't need alot...maybe 4-6% of standardized ginsenoside.

* A balanced gut PH (which is about 7 to 7.5 ph) helps to metabolize drugs and herbs...prevents leaky gut syndrome.

* Now a person with high stress might see a bigger impact using this formula. It's also possible that 30-35% users might not see results, ruling out certain metabolic conditions of course too.

* Beta blockers and PDE 5 inhibitors (E.D. aka erectile dysfunction drugs) works also in combination with ginseng by relaxing blood vessels and slowing heart rate...which  improve blood flow and decrease blood pressure.


https://www.ncbi.nlm.nih.gov/pmc/article...o=0.471698

https://www.ncbi.nlm.nih.gov/m/pubmed/22315456/

Actions and interactions of estradiol and glucocorticoids in cognition and the brain: Implications for aging women.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501869/

https://www.researchgate.net/publication...rain_cells

https://en.m.wikipedia.org/wiki/Ginsenoside

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162649/