16-05-2017, 07:11 AM
I believe I stumbled upon new information to further feminize and fine tune drug metabolism for NBE and HRT, (e.g. lock down how long does certain herbs/pharma drugs take become active in humans....and what pathways do they take..too funny). I still have to extrapolate (big word, haha) the info for human consumption. For instance, co-administration of estradiol and prolactin does indeed look doable. In other words, raising PRL (prolactin) inhibits LH (lutenizing hormone) which turns testosterone production off (or reduces it significantly) while co-administration of E2 (estradiol), or phytoestrogens if strong enough (like authentic PM).
So I'll be periodically updating this list:
So I'll be periodically updating this list:
(14-01-2016, 07:57 PM)Lotus Wrote: Genes Involved in Testosterone Syntheses with corsponding inhibitors.
CYP1A2(also makes an Estrogen).....,cimetidine (inhibits)
CYP1B1(also makes an Estrogen)
CYP2B1– apigenin,Curcumin
CYP2B6– apigenin,Curcumin,Kaempferol
CYP2A3- lignans, genistein, Kaempferol
CYP2C11(Men Only)
CYP3A4 - lignans, Kaempferol, genistein, Curcumin (cimetidine, inhibits), sesame seeds and oil. Piperine
CYP3A5 - lignans, Kaempferol, genistein, Curcumin
CYP3A9 - vitamin D3
CYP19A1 -aromatase , white peony, forskolin, oleic acid,
Some Herbs and the anti androgen chemicals in them.
apigenin(chamomille)
Quercetin (chamomille)
genistein(Soy)
Curcumin(Vanalla, Turmeric)
Kaempferol(Peony, Dill)
lignans (Flax)
steroidogenic enzymes represent targets for complete suppression of systemic and intratumoral androgen levels, an objective that is supported by the clinical efficacy of the CYP17 inhibitor abiraterone.
Estrogen pathways for mammary density
HSD3B1, (catalyses the biosynthesis of all classes of hormonal steroids)
HSD17B1 (estrogen activation and androgen inactivation)
CYP27B1, CYP24 metabolizes enzymes in mammary cells, Vit.D elongates breast
CYP1A1 (polypeptide protein)
CYP1A2 (estrogen link)
CYP17A1 (modifies estrogen / inhibits DHT)
CYP19A1 (aromatase)
CYP1B1 (breaks down fats, aka-lipids)
COMT-(catechol-O-methyltransferase)
UGT1A1-(uridine diphospho-glucuronosyltransferase -(catalyzes estrogen)
SULT1A1, SULT1E1- (sulfotransferases)
ESR1, ESR2-(estrogen receptors alpha and beta)
H2 receptor antagonist, cimetidine (90% bioavailability)
H1 receptor antagonist, rantindine (50% bioavailability)
CYP17 and CYP1A1-1 play a role in the pathogenesis of fibroadenoma. Meaning something like cigarette smoke can have direct role on the CYP1A1 enzyme metabolism, e.g. progression of fibroadenomas. In other words, as bad as smoking is, 2nd hand smoke can further exacerbate fibroadenomas.
Here's a new one called CYP2C8, which metabolizes fatty acids. another CYP17's , which CYP17A modifies estrogen metabolism.
CYP2C8- lignans-Quercetin, linoleic acid
CYP17 -lignans-green tea (inhibits DHT)
CYP17A modifies estrogen metabolism
When used in quantities typical for flavoring food, black pepper is not likely to affect the disposition of most medications. However, excessive use of black pepper or intake of dietary supplements formulated with P. nigrum or P. longum extracts may produce clinically significant interactions with drugs. This may be of particular concern when CYP3A and/or ABCB1 substrates are ingested concomitantly with piperine or piperamides in excess of 10 mg.