01-01-2017, 01:22 AM
(31-12-2016, 08:52 PM)Atom Wrote: Do you think MSM with other anti-androgens or with PM will have a similar effect?
Yes, it seems quite possible......meaning the science is there, although yet to be deciphered on our part....lol the world is our oyster.
I sought to find a natural (herbal) derivative of " Lactone " to Spirolactone, and wow I wasn't disappointed, it's like peeling an onion (the jumbo colossal types they use for awesome blossoms or bloomin' onion, lmao). I used wiki to help explain this process I see, though sources need to be confirmed ( I feel confident we're on the right track though). I'll have to break all this down in the coming New Years.........thank you Atom for the query. So, the CYP2C9 enzyme pathway we'll help us to incorporate a theory of " PM + CYP2C9 + MSM " . And that's only the beginning, meaning other variations will certain be gained from exploring this alternative.
Natural sources
Edit
Naturally occurring lactones are mainly saturated and unsaturated γ- and δ-lactones, and to a lesser extent macrocyclic lactones. The γ- and δ-lactones are intramolecular esters of the corresponding hydroxy fatty acids. They contribute to the aroma of butter, cheese and various foods and fruits. Cyclopentadecanolide is responsible for the musklike odor of angelica root oil. Of the naturally occurring bicyclic lactones, phthalides are responsible for the odors of celery and lovage oils, and coumarin for woodruff.[3] Lactone rings occur widely as building blocks in nature, such as in ascorbic acid, kavain, nepetalactone, gluconolactone, hormones (spironolactone, mevalonolactone), enzymes (lactonase), neurotransmitters (butyrolactone, avermectins), antibiotics (macrolides like erythromycin; amphotericin B), anticancer drugs (vernolepin, epothilones), phytoestrogens(resorcylic acid lactones, cardiac glycosides).
https://en.m.wikipedia.org/wiki/Lactone
Natural sesquiterpen lactones as acetylcholinesterase inhibitors
Abstract
Background and the purpose of the study: The amount of elder people who suffer from Alzheimer disease is continuously increasing every year. Cholinesterase inhibitors have shown to be effective in alleviating the symptoms of the disease, thus opening a field of research for these treatments. Herbal products, owning a reputation as effective agents in many biological studies are now drawing attention for inhibiting acetylcholinesterase, in other words, Alzheimer disease. In the present study, the ability of three sesquiterpene lactones from Inula oculus-christi and I. aucheriana to inhibit AChE has been evaluated through Ellman assay. Materials and Methods: Gaillardin and pulchellin C were obtained from I. oculus-christi and britannin from I. aucheriana by chromatographic methods. They were dissolved in methanol in concentration of 3 mg/mL and the AChEI activity of the compounds was determined by Ellman method using Acethylthiocholine iodide as the substrate and 5, 5'-dithiobis-2-nitrobenzoic acid as the reagent, in 96-well plates at 405 nm. Results: AChEI activity of the examined compounds was obtained as 67.0, 25.2 and 10.9% in concentration of 300 µg/L for gaillardin, britannin and pulchellin C, respectively. Conclusion: Among the three sesquiterpene lactones, gaillardin with 67% inhibition of AChE could be considered a good candidate for future Alzheimer studies.
https://www.researchgate.net/publication...inhibitors
https://en.m.wikipedia.org/wiki/Sesquiterpene_lactone
https://en.m.wikipedia.org/wiki/Apigenin
https://en.m.wikipedia.org/wiki/CYP2C9
Mechanism of CYP2C9 inhibition by flavones and flavonols.
Si D1, Wang Y, Zhou YH, Guo Y, Wang J, Zhou H, Li ZS, Fawcett JP.
Author information
Abstract
This article describes an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) and flavonols (galangin, fisetin, kaempferol, morin, and quercetin). With the exception of flavone, all flavonoids were shown to inhibit CYP2C9-mediated diclofenac 4'-hydroxylation in the CYP2C9 RECO system, with K(i) value
Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism.
Spector AA1, Kim HY2.
Author information
Abstract
Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of PUFA epoxides are incorporation into phospholipids and hydrolysis to the corresponding PUFA diols by soluble epoxide hydrolase. Inhibitors of soluble epoxide hydrolase stabilize PUFA epoxides and potentiate their functional effects. The epoxyeicosatrienoic acids (EETs) synthesized from arachidonic acid produce vasodilation, stimulate angiogenesis, have anti-inflammatory actions, and protect the heart against ischemia-reperfusion injury. EETs produce these functional effects by activating receptor-mediated signaling pathways and ion channels. The epoxyeicosatetraenoic acids synthesized from eicosapentaenoic acid and epoxydocosapentaenoic acids synthesized from docosahexaenoic acid are potent inhibitors of cardiac arrhythmias. Epoxydocosapentaenoic acids also inhibit angiogenesis, decrease inflammatory and neuropathic pain, and reduce tumor metastasis. These findings indicate that a number of the beneficial functions of PUFA may be due to their conversion to PUFA epoxides. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance".
Published by Elsevier B.V.
https://www.researchgate.net/publication...metabolism