12-12-2016, 04:07 AM
White peony was discovered to be a nontoxic chaperone- inducing compounds that promotes DNA binding. On top of what we now know about WP it seems to have this extra benefit that improves DNA binding. I don't believe we see any other NBE supplement in the arsenal that can do as many things (thus far documented). I'll make present the other scientific info posted here.
paeoniflorin (white peony) enhances phosphorylation and acquisition of the (DNA)deoxyribonucleic acid–binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1.
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Paeoniflorin, a novel heat shock protein–inducing compound
[size=undefined]Dai Yan,[/size]1 Kiyoto Saito,1,2 Yuri Ohmi,1 Noriyo Fujie,1 and Kenzo Ohtsuka1
1Laboratory of Cell and Stress Biology, Department of Environmental Biology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan 2Department of Medical Imaging and Information, Graduate School, Suzuka University of Medical Science, 1001-1 Suzuka, Mie 510-0293, Japan
Abstract Heat shock proteins (HSPs) are induced by various physical, chemical, and biological stresses. HSPs are known to function as molecular chaperones, and they not only regulate various processes of protein biogenesis but also function as lifeguards against proteotoxic stresses. Because it is very useful to discover nontoxic chaperone- inducing compounds, we searched for them in herbal medicines. Some herbal medicines had positive effects on the induction of HSPs (Hsp70, Hsp40, and Hsp27) in cultured mammalian cells. We next examined 2 major constituents of these herbal medicines, glycyrrhizin and paeoniflorin, with previously defined chemical structures. Glycyrrhizin had an enhancing effect on the HSP induction by heat shock but could not induce HSPs by itself. In contrast, paeoniflorin had not only an enhancing effect but also an inducing effect by itself on HSP expression. Thus, paeoniflorin might be termed a chaperone inducer and glycyrrhizin a chaperone coinducer. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid–binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 g/ mL (166.4 . To our knowledge, this is the first report on the induction of HSPs by herbal medicines.
https://www.ncbi.nlm.nih.gov/pmc/article...-4-378.pdf
paeoniflorin (white peony) enhances phosphorylation and acquisition of the (DNA)deoxyribonucleic acid–binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1.
_______________________________________________
Paeoniflorin, a novel heat shock protein–inducing compound
[size=undefined]Dai Yan,[/size]1 Kiyoto Saito,1,2 Yuri Ohmi,1 Noriyo Fujie,1 and Kenzo Ohtsuka1
1Laboratory of Cell and Stress Biology, Department of Environmental Biology, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan 2Department of Medical Imaging and Information, Graduate School, Suzuka University of Medical Science, 1001-1 Suzuka, Mie 510-0293, Japan
Abstract Heat shock proteins (HSPs) are induced by various physical, chemical, and biological stresses. HSPs are known to function as molecular chaperones, and they not only regulate various processes of protein biogenesis but also function as lifeguards against proteotoxic stresses. Because it is very useful to discover nontoxic chaperone- inducing compounds, we searched for them in herbal medicines. Some herbal medicines had positive effects on the induction of HSPs (Hsp70, Hsp40, and Hsp27) in cultured mammalian cells. We next examined 2 major constituents of these herbal medicines, glycyrrhizin and paeoniflorin, with previously defined chemical structures. Glycyrrhizin had an enhancing effect on the HSP induction by heat shock but could not induce HSPs by itself. In contrast, paeoniflorin had not only an enhancing effect but also an inducing effect by itself on HSP expression. Thus, paeoniflorin might be termed a chaperone inducer and glycyrrhizin a chaperone coinducer. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid–binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 g/ mL (166.4 . To our knowledge, this is the first report on the induction of HSPs by herbal medicines.
https://www.ncbi.nlm.nih.gov/pmc/article...-4-378.pdf