20-04-2016, 12:16 AM
(19-04-2016, 10:03 PM)Lotus Wrote:(13-04-2016, 08:09 PM)spanky Wrote: Here's an article on some research involving effect of diets high in medium chain fatty acids such as caprylic acid on LDL as compared to diet high in oleic acid.
http://ajcn.nutrition.org/content/79/4/564.full
Spanky,
Oddly enough, while I was at looking MCFA's (caprylic acid and others) I stumbled upon that dutasteride contains medium chained fatty acids, (see below).
Dutasteride, a synthetic 4- azasteroid compound, is an antiandrogen with the chemical name (5a, 17β) -N- [2, 5 bis (trifluoromethyl) phenyl] -3- oxo-4-azaandrost -1-ene- 17- carboxamide. Dutasteride is indicated for the treatment of symptomatic benign prostate hyperplasia (BPH) in men with enlarged prostate glands. Dutasteride, a synthetic 4-azasteroid compound is a selective inhibitor of the type 1 and type 2 isoforms of steroid 5a-reductase, an intracellular enzyme that converts testosterone to 5a-dihydrotestosterone. The empirical formula of Dutasteride is C27H30F6N2O2. Dutasteride is a white to off-white colored powder and stable under ordinary conditions. The melting point is 245°C - 245.5°C.
Dutasteride is soluble in ethanol (44 mg/mL), methanol (64 mg/mL), and polyethylene glycol 400 (3 mg/mL), but it is insoluble in water. Dutasteride has a partition coefficient, Log P = 5.609 ± 0.618.
[0003] Commercially available soft gel capsule formulations (e.g., Avodart®, which is produced by Glaxo Smithkline Pharmaceuticals), is a soft gelatin capsule used in the treatment of BPH, which contains 0.5 mg dutasteride dissolved in a mixture of
mono/diglycerides of caprylic/capric acid (Capmul MCM) (349.5mg) and butylated hydroxytoluene (0.035mg). However, the manufacture of soft gel capsules is a slow and burdensome process, and therefore the manufacture of soft gel capsules is cost intensive and inefficient. [0004] Consequently, there is a need for improved hard gel capsule formulations that reduce manufacturing costs, while maintaining the bioavailability and stability of the soft gel dosage forms.
SUMMARY
[0005] According to one embodiment, a liquid-filled hard gel capsule pharmaceutical formulation is provided. The liquid-filled hard gel capsule formulation comprises a non- emulsified mixture disposed in a hard capsule shell, wherein the non-emulsified mixture comprises about 0.1 to about 5% by weight of at least one active pharmaceutical ingredient, about 50 to about 95% by weight medium chain triglycerides, and about 5 to about 25% by weight medium chain mono/diglycerides, wherein the medium chain triglycerides and medium chain mono/diglycerides are present at a ratio by weight of from about 10: 1 to about 5: 1.
[0006] According to another embodiment, another liquid-filled hard gel capsule pharmaceutical formulation is provided. The liquid- filled hard gel capsule pharmaceutical formulation comprises a non-emulsified mixture disposed in a hard capsule shell, wherein the non-emulsified mixture comprises about 0.1 to about 5% by weight of at least one active pharmaceutical ingredient; about 50 to about 95% by weight long chain triglycerides; and about 5 to about 25% by weight medium chain mono/diglycerides, wherein the long chain triglycerides and medium chain mono/diglycerides are present at a ratio by weight of from about 10: 1 to about 5: 1.
http://www.google.com/patents/WO2013074205A1?cl=en
Caprylic Capric Triglycerides
http://www.ingredientstodiefor.com/item/...rides/464/
Thanks for the find, Lotus. Could it be why some report breast growth as a side effect of dutasteride? In any event, it sounds like not a very large amount of medium chain triglycerides.
Boobs for Peace!