17-03-2016, 02:10 AM
This study displays test results of 47 old female (or ENDOCRINOLOGY URINE):
http://nutripath.com.au/wp-content/uploa...4-hour.pdf
URINE E1 METABOLITE RATIO 2(OH):16a(OH)
A ratio of 2-OH Estrone to 16aOH Estrone greater than 2.0 is desirable.
A ratio less than 2.0 may increase the risk of cancer.
Patients with a ratio less than 2.0 may benefit from a modification in diet and
lifestyle.
The supplementation of the diet with phytoestrogens may further improve the ratio.
A high protein, low fat diet rich in dietary sources of indole-3-carbinol may also
improve the 2/16 ratio. Diindolylmethane (DIM) has also been shown to improve the 2/16 ratio.
URINE 4 (OH)E1 along with 2 (OH)E1 comprises what are called the catechol estrogens. Unlike 2-hydroxyestrone, this estrone has been shown to be a free radical generator and a very powerful estrogen. High levels occur in the urine following severe exercise and may indicate a relative lack of the enzyme, catecholamine methyl
transferase. Increases of dietary folic acid may help rectify this situation. This metabolite may eventually be one of the more important metabolites related to increased risk in female cancers.
NOTES:
Protective: 2-OH E2, 2-OH E1, 2-Methoxy E1.
Anti-Proliferative: 2-Methoxy E2.
Carcinogen & Active Estrogen: 16 alpha OH E1, 4-OH E1.
Active Estrogens: E2, E1, E3.
DIM/Indole-3-Carbinol action is to shift estrogen metabolism to increase levels of 2
OH & 2 Methoxy metabolites:
E1 conversion to 2-OH E1 & 2-methoxy E1.
E2 conversion to 2-OH E2 & 2-methoxy E2.
URINE Hydroxy & Methoxy E1
After hydroxylation, both 2-OH and 4-OH can undergo another step called methylation. Methylation turns both of these metabolites into substances that are even more water-soluble. 2-OH becomes 2-methoxyestrone, which may support women's breast health, and 4-OH becomes 4-methoxyestrone, which is a very weak estrogen. Literature indicates that the Methoxy's are apoptotic. 4(OH)E1 along with 2(OH)E1 comprises what are called the catechol estrogens and unlike 2(OH)E1, this estrone has been shown to be a free radical generator and a very powerful estrogen. High levels occur in the urine following severe exercise and may indicate a relative lack of the enzyme, catecholamine methyl transferase. Increases of dietary folic acid may help rectify this situation. This metabolite may eventually be one of the more important metabolites related to increased risk in female cancers.
http://nutripath.com.au/wp-content/uploa...4-hour.pdf
URINE E1 METABOLITE RATIO 2(OH):16a(OH)
A ratio of 2-OH Estrone to 16aOH Estrone greater than 2.0 is desirable.
A ratio less than 2.0 may increase the risk of cancer.
Patients with a ratio less than 2.0 may benefit from a modification in diet and
lifestyle.
The supplementation of the diet with phytoestrogens may further improve the ratio.
A high protein, low fat diet rich in dietary sources of indole-3-carbinol may also
improve the 2/16 ratio. Diindolylmethane (DIM) has also been shown to improve the 2/16 ratio.
URINE 4 (OH)E1 along with 2 (OH)E1 comprises what are called the catechol estrogens. Unlike 2-hydroxyestrone, this estrone has been shown to be a free radical generator and a very powerful estrogen. High levels occur in the urine following severe exercise and may indicate a relative lack of the enzyme, catecholamine methyl
transferase. Increases of dietary folic acid may help rectify this situation. This metabolite may eventually be one of the more important metabolites related to increased risk in female cancers.
NOTES:
Protective: 2-OH E2, 2-OH E1, 2-Methoxy E1.
Anti-Proliferative: 2-Methoxy E2.
Carcinogen & Active Estrogen: 16 alpha OH E1, 4-OH E1.
Active Estrogens: E2, E1, E3.
DIM/Indole-3-Carbinol action is to shift estrogen metabolism to increase levels of 2
OH & 2 Methoxy metabolites:
E1 conversion to 2-OH E1 & 2-methoxy E1.
E2 conversion to 2-OH E2 & 2-methoxy E2.
URINE Hydroxy & Methoxy E1
After hydroxylation, both 2-OH and 4-OH can undergo another step called methylation. Methylation turns both of these metabolites into substances that are even more water-soluble. 2-OH becomes 2-methoxyestrone, which may support women's breast health, and 4-OH becomes 4-methoxyestrone, which is a very weak estrogen. Literature indicates that the Methoxy's are apoptotic. 4(OH)E1 along with 2(OH)E1 comprises what are called the catechol estrogens and unlike 2(OH)E1, this estrone has been shown to be a free radical generator and a very powerful estrogen. High levels occur in the urine following severe exercise and may indicate a relative lack of the enzyme, catecholamine methyl transferase. Increases of dietary folic acid may help rectify this situation. This metabolite may eventually be one of the more important metabolites related to increased risk in female cancers.