06-02-2016, 05:29 AM
(06-02-2016, 05:03 AM)MarcyAno Wrote: Have you seen this article?
http://www.altmedrev.com/issues/81-volum...staxanthin
Seems this astaxanthin you've uncovered is some interesting stuff indeed!
Great find on the review Marcy, thanks.
I like what astaxanthin does, and the small dose (up to 12 mgs) makes it an attractive option. But the other huge plus is its ability to inhibit DHT, coupled with the other antioxidant, weight management, pain relief, I'm like why the F*** haven't we seen this earlier. In the study below, I see astaxanthin kicking SP's butt when they where combined together, see for yourself. (That's just my opinion though).
(04-02-2016, 05:57 AM)Lotus Wrote: I'm seeing red,
Chinese Red Yeast Rice Inhibition of Prostate Tumor Growth in SCID mice
http://www.ncbi.nlm.nih.gov/pmc/articles...320100.pdf
Gene expression of androgen synthesizing enzymes and androgen receptor (AR)
In RYR-fed animals, HSD3B2, AKR1C3 and SRD5A1 gene expression was downregulated more than threefold in LNCaP tumors, and more than twofold in LNCaP-AR tumors (P<0.05) (Figure 8A, 8B and 8C). The RYR diet also decreased AR expression more than twofold in androgen-independent SCID tumors (P<0.05) (Figure 9). The transcription levels of HSD3B2, AKR1C3 and SRD5A1 and AR were higher in androgen-independent tumors than androgen-dependent tumors (P<0.05) (Figures 8 and 9).
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A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxanthin and Saw Palmetto lipid extract in vitro.
J Herb Pharmacother. 2005;5(1):17-26.
Abstract
Inhibition of 5alpha-reductase has been reported to decrease the symptoms of benign prostate hyperplasia (BPH) and possibly inhibit or help treat prostate cancer. Saw Palmetto berry lipid extract (SPLE) is reported to inhibit 5alpha-reductase and decrease the clinical symptoms of BPH. Epidemiologic studies report that carotenoids such as lycopene may inhibit prostate cancer. In this investigation the effect of the carotenoid astaxanthin, and SPLE were examined for their effect on 5alpha-reductase inhibition as well as the growth of prostatic carcinoma cells in vitro. These studies support patent #6,277,417 B1. The results show astaxanthin demonstrated 98% inhibition of 5alpha-reductase at 300 microg/mL in vitro. Alphastat, the combination of astaxanthin and SPLE, showed a 20% greater inhibition of 5alpha-reductase than SPLE alone n vitro. A nine day treatment of prostatic carcinoma cells with astaxanthin in vitro produced a 24% decrease in growth at 0.1 mcg/mL and a 38% decrease at 0.01 mcg/mL. SPLE showed a 34% decrease at 0.1 mcg/mL.
CONCLUSIONS: Low levels of carotenoid astaxanthin inhibit 5alpha-reductase and decrease the growth of human prostatic cancer cells in vitro. Astaxanthin added to SPLE shows greater inhibition of 5alpha-reductase than SPLE alone in vitro.
PMID 16093232 [PubMed - indexed for MEDLINE]
Anti-cancer potential of flavonoids: recent trends and future perspectives
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824783/