27-01-2016, 03:37 AM
(27-01-2016, 03:15 AM)Atom Wrote:(27-01-2016, 12:16 AM)Lotus Wrote: Cool, you're dailed in on this, I will enjoy reading it. But the preliminary indications (imo) is that's it's more than just a dual (type 1 and type 2) Inhibitor, meaning it also inbitis C17 in the sebum (via the sebaceous gland),
great stuff. Thanks
The primary component appears to be a chemical called embelin, which a number of studies have done to asses its anti-androgen abilities for treatment of prostate conditions, acne, and also as a contraceptive for women. Some studies like the one below on rabbits say that progesterone increased as well, while other another study I saw on female rats said that progesterone and estradiol was lowered, which they believed to be due to an effect on the ovaries, but overall I couldn't find anything significant one way or another on how it would effect estrogen in humans, and from I can tell there have been contradictory results on how and if it affects estrogen. (The one where the study on female rats is mentioned - A REVIEW ON THE PHARMACOLOGY OF EMBELIA RIBES BURM.F. A THREATENED MEDICINAL PLANT http://goo.gl/DTCcqM )
This next one is a study on male rabbits
Quote:Changes in the concentrations of testosterone, luteinising hormone and progesterone associated with administration of embelin.
Githui EK1, Makawiti DW, Midiwo JO.
The mode of action of embelin, a naturally occurring plant benzoquinone with male fertility regulating potential, was investigated. Sexually mature white New Zealand male rabbits were injected intra-muscularly with embelin (30 mg/kg body wt) on alternate days for 14 days (7 injections). Blood was collected on alternate days over 27-day period from the beginning of embelin administration. Testosterone and progesterone levels were measured by radioimmunoassay and luteinising hormone (LH) by mouse interstitial cell testosterone bioassay. There was a marked reduction of testosterone concentrations within two days of embelin administration and up to 90% reduction by the 6th day. LH showed a corresponding rise with the falling testosterone levels. Similarly, there was rapid increase in progesterone levels with the administration of embelin. Both the concentrations of progesterone and LH declined when embelin dosage was stopped. Evidence from the observed changes in the levels of the three hormones suggest that embelin disrupts production of testosterone at the testicular level.
Ok thanks,
The surge of LH- llutenizing hormone(s) is generally temporary, why?, imo its a feedback control (hemostasis) when LH is being suppressed. When the surge is over, the signaling to the hypothalamus to produce more T is suppressed, in other words, testes get shut down. GnRH analogues causes this flare too.
https://en.m.wikipedia.org/wiki/Gonadotr...ne_agonist
http://www.sciencedirect.com/science/art...3406001027