27-01-2016, 12:00 AM
This is something I just found by accident, I am going to order some, you can buy it under the name Vidanga which is the Sanskrit name, a well known Ayurvedic plant, it is called https://en.wikipedia.org/wiki/Embelia_ribes
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Quote:Extract of E. ribes showed effective inhibition of 5α-
reductase resulting in higher residual levels (40 %) of
testosterone at 125 μg /mL and 56 % at 500 μg /mL.
However, T. chebula, T. bellerica and V. negundo
showed lower inhibition resulting in lower levels of
residual testosterone (13-26 % at 125 μg /mL and 17-40
% at 500 μg /mL). Dutasteride exhibited an inhibition of
5α-reductase similar to that of E. ribes at concentration
of 2 mM (1056 μg /mL). Thus of all the plants
investigated here, extract of E. ribes was found to be the
most potent inhibitor of type I 5α-reductase.
The inhibition of 4-androstenedione production in
presence of varying concentration of plant extracts after
24 h is shown in Fig. 3. All the plant extracts inhibited
the production of 4-androstenedione significantly (76-87
%) at concentration of 500 and 1000 μg /mL. E. ribes
inhibited the production of 4-Androstenedione by 57 %
at a concentration of 125 μg/mL whereas it exhibited 87
% inhibition at a concentration of 1000 μg/mL. E. ribes
showed significant reduction (87 %) in the production of
4-Androstenedione at (1000 μg /mL) which indicated
significant inhibition of 5α-reductase. Dutasteride
showed 98 % inhibition of 4-Androstenedione
production at concentration of 2 mM (1056 μg /mL). The
above results indicated that extract of E. ribes was the
most potent inhibitor of 5α-reductase with IC 50 value of
100 μg /mL as against other plant extracts which showed
IC 50 values in the range of 260-360 μg /mL as shown in
Table 2.
CONCLUSION
The present study is an attempt to find novel type I 5α-
reductase inhibitors. Earlier investigations of type I 5α-
reductase inhibitors include use of plant extracts such as
Saw palmetto, Pygeum africanum, Artocarpus incisus,
Thujaorientalis, 25 Laminaria
saccharina, Salviaofficinalis,
Thymus officinalis, Arnica Montana, Mentha
piperita and Rosamarinus officinalis 26 . These
experimental results indicated that methanolic extract of
E. ribes was a potent inhibitor of type I 5α-reductase and
had antimicrobial activity against P. acnes and S.
epidermidis may be sufficient to control acne vulgaris.
This study revealed that extracts of Embelia ribes, Vitex
negundo, Terminalia chebula and Terminalia bellerica
could be used in herbal formulations as an alternative
treatment for acne
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