17-10-2015, 04:08 AM
(17-10-2015, 03:25 AM)eloise614 Wrote: I didn't mean to get you going, Lotus Okay, well maybe I did .
To add onto this: because androstenedione (or, Δ4-dione) can be converted to estrogens, people taking this supplement may have estrogenic side effects.
In addition to its role as a precursor to testosterone in the body, Δ4-dione has slight androgenic properties in its own right, acting as a weak partial agonist of the androgen receptor. However, in the presence of full agonists like testosterone or dihydrotestosterone (DHT), due to its lower intrinsic activity in comparison, it has antagonistic effects, and can behave more like an antiandrogen.
Eloise.
This is fun. When DHT is down-regulated the E2 signal is upregulated, and in this instance, the androstenedione pathway will prevail. In addition, this make androstenedione and DHEA a pure pro-aromatase.
Here's something to ponder: If women can modulate more of their 5ar activity (in ovaries) it could up regulate progesterone, giving way to aromatizable androgens.
Btw, it's nice to see creative thinking, I appreciate that. Especially considering original thinkers have the ability to lead others, they don't need to use other peoples thoughts to express themselves.....