20-08-2015, 05:04 AM
Polyunsaturated fats and prostaglandins stimulate the expression of aromatase, the enzyme that synthesizes estrogen.
Generally, ingested fats show up in adipose tissue depots and in the bloodstream (in lipoproteins or as FFA) and the ultimate storage site is determined by the places where blood flows the greatest. Women, for instance, store a greater proportion of ingested fats in the subcutaneous adipose tissue depots than men because of these regional blood flow differences (Jensen, Sarr, Dumesic, Southorn, & Levine, 2003).
In principle, on activation by the lipolytic hormones, short, polyunsaturated fats (e.g., linoleate) would be mobilized in preference to longer, saturated fats because they are more accessible to the water-soluble enzyme, HSL, which catalyzes the release of fatty acids from glycerol. (To add another layer of complexity, depending on the circumstances, adipose tissue depots contribute differentially to the blood FFA pool [Mittendorfer, Liem, Patterson, Miles, & Klein, 2003]). Nonetheless, in reality, on average, plenty of saturated (e.g., stearate and palmitate) and monounsaturated fats (e.g., oleate and palmitoleate) are released in addition to polyunsaturated fats, so when fats are mobilized a mixture is available for use as fuel by tissues elsewhere (Staiger et al., 2004).
http://www.andrewkimblog.com/2013/02/dr-...fe-of.html
Generally, ingested fats show up in adipose tissue depots and in the bloodstream (in lipoproteins or as FFA) and the ultimate storage site is determined by the places where blood flows the greatest. Women, for instance, store a greater proportion of ingested fats in the subcutaneous adipose tissue depots than men because of these regional blood flow differences (Jensen, Sarr, Dumesic, Southorn, & Levine, 2003).
In principle, on activation by the lipolytic hormones, short, polyunsaturated fats (e.g., linoleate) would be mobilized in preference to longer, saturated fats because they are more accessible to the water-soluble enzyme, HSL, which catalyzes the release of fatty acids from glycerol. (To add another layer of complexity, depending on the circumstances, adipose tissue depots contribute differentially to the blood FFA pool [Mittendorfer, Liem, Patterson, Miles, & Klein, 2003]). Nonetheless, in reality, on average, plenty of saturated (e.g., stearate and palmitate) and monounsaturated fats (e.g., oleate and palmitoleate) are released in addition to polyunsaturated fats, so when fats are mobilized a mixture is available for use as fuel by tissues elsewhere (Staiger et al., 2004).
http://www.andrewkimblog.com/2013/02/dr-...fe-of.html