09-02-2015, 06:45 PM
Androgens from adrenal pathway (DHEA & DHEAS) go through a back doors of sorts to 4 Dione (androstenedione), which in turn can be synthesized by aromatase to E1.
Btw, did you know that the skin acts as one big hormone receptor!, that's right, beneath the layers of skin sits all the hormone molecules. Estrogens sit inside the fat tissues (aka adipose), the process of first pass metabolism is generally ignored, meaning the liver. And in this case offers one of the biggest opportunities to get at hormones that are in the "free" state (the active hormones).
This illustrates a transdermal application, but you get the idea.
Btw, did you know that the skin acts as one big hormone receptor!, that's right, beneath the layers of skin sits all the hormone molecules. Estrogens sit inside the fat tissues (aka adipose), the process of first pass metabolism is generally ignored, meaning the liver. And in this case offers one of the biggest opportunities to get at hormones that are in the "free" state (the active hormones).
This illustrates a transdermal application, but you get the idea.