[Lotus]

I'm not trying to sugar coat Reishi, there's some known interactions like with any herb/med that everyone should be aware of if you're currently on or will consider using Reishi. consider. As always consult with your healthcare professionals.

Here's some info concerning Reishi, some of which has been already provided, thank you to those who contributed:

Ganoderma Lucidum Side Effects
http://www.livestrong.com/article/112069...e-effects/

Ganoderma Lucidum-Drug Interactions
http://cordyceps-sinensis.org/ganoderma-...de-effects

Reishi mushroom (Ganoderma lucidum)
http://v1.naturalstandard.com/naturalsta...rsion=true

Oral doses of 150-300mg three to four times daily have been standardized to contain 10-12.5% polysaccharides and 4% triterpenes per dose.

Dosing:
Adult (age ≥18):
Oral:
General: Doses of 2-6g raw reishi or an equivalent dosage of concentrated extract has been taken daily with meals.
Cancer: Doses of 600-1,800mg reishi mushroom as Ganopoly® has been taken three times daily for up to 12 weeks (10; 11; 16).
Chronic hepatitis B: Ganopoly® has been taken three times daily (dose unavailable) for 12 weeks (17).
Coronary heart disease: Ganopoly® has been taken three times daily (dose unavailable) for 12 weeks (18).
Diabetes: A dose of 1,800mg Ganopoly® has been taken three times daily for 12 weeks (19).
Hypertension: A clinical trial reported using linzhi extract (reishi) in daily doses of 55mg for four weeks (20).
Poisoning (Russula subnigricans): A dose of 100g reishi mushroom has been boiled in 600mL water per dose (21).
Postherpetic neuralgia: In clinical reports of reishi used in pain management for herpes zoster (shingles), reishi has been administered in doses from 36-72g dry weight in three divided doses daily for up to 10 days (22).
Proteinuria: Doses of 500-1,125mg reishi mushroom has been taken daily for up to 26 months (12; 13; 14).


Adenosine: Reishi mushroom contains high levels of adenosine (34).
Analgesics: Theoretically, reishi mushroom may increase the effects of analgesics. Reishi mushroom plus the traditional Chinese medicine (TCM) herbal combination formula, San Miao San (SMS), was reported to reduce pain in patients with active rheumatoid arthritis when taken in combination with standard arthritis medications (35). However, these effects cannot be definitively attributed to reishi mushroom because other herbs were also taken.
Anesthetics: Based on secondary sources, reishi mushroom may interact with anesthetics.
Antibiotics: Based on in vitro evidence, reishi mushroom and cefazolin may have synergistic effects against Bacillus subtilis and Klebsiella oxytoca (36); the combination of Ganoderma lucidum with ampicillin, cefazolin, oxytetracycline and chloramphenical may also have additive, antasgonistic or synergistic interactions (36).
Anticoagulants and antiplatelets: Based on laboratory evidence, reishi may affect platelet aggregation (15). Reishi mushroom contains high levels of adenosine, which may be responsible for inhibition of platelet aggregation (34; 37), but there is controversy in this area. Concomitant therapy with reishi and anticoagulants or NSAIDs may theoretically lead to additive effects or increased risk of bleeding due to potential prolongation of prothrombin time.
Antidiabetic agents: Based on animal evidence, reishi may reduce blood sugar levels and increase insulin levels (31; 32).
Antihypertensive drugs: Based on animal study, mycelium isolated from reishi mushroom (28) and a peptidoglycan of reishi (38) may have hypotensive effects. In laboratory study, the 70% MeOH extract of Ganoderma lucidum demonstrated an inhibitory activity on angiotensin converting enzyme (39).
Antilipemic agents: In laboratory study, reishi can inhibit the rate-limiting enzyme HMG-CoA in cholesterol biosynthesis (40).
Antineoplastic agents: Based on in vitro and animal studies, reishi mushroom may theoretically increase the effects of antineoplastic agents (3; 4; 5; 8; 9; 10; 11; 24; 30; 41; 42; 43; 44; 45; 46; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56).
Antiretroviral agents, protease inhibitors: Based on laboratory evidence, triterpenes isolated from Ganoderma lucidum may inhibit HIV or HIV protease (2; 57).
Antiviral agents: Based on laboratory evidence, the acidic protein bound polysaccharide (APBP) isolated from capophores of Ganoderma lucidum may have synergistic effects when administered with acyclovir (58).
Aspirin/aspirin-containing drugs: Based on laboratory evidence, reishi may affect platelet aggregation (15); adjustments may be necessary if the patient is receiving therapy aspirin.
Cardiovascular agents: Based on animal study, mycelium isolated from reishi mushroom (28) and a peptidoglycan of reishi (38) may have hypotensive effects. In laboratory study, the 70% MeOH extract of Ganoderma lucidum demonstrated an inhibitory activity on angiotensin converting enzyme (39).
CNS stimulants: Theoretically, use of reishi and amphetamines may result in an antagonistic effect.
Hepatotoxic agents: Theoretically, the risk of liver damage may increase when reishi mushroom powder is taken with drugs that are known to damage the liver (23). However, another hepatoprotectant study performed in rats showed that extracts from reishi-reduced free radicals that harm the liver (33)
Immunomodulators: Based on in vitro animal evidence, Ling zhi-8 may be a potent immunosuppressive drug in vitro able to delay rejection in allogeneic pancreatic islet transplantation (59).
Neurologic agents: Ganoderma lucidum spore preparations have been used in patients with atrophic myotonia (7). Based on secondary sources, use of reishi and amphetamines may result in an antagonistic effect.
Thyroid hormones: Based on secondary sources, reishi mushroom may interact with thyroid agents.