16-07-2014, 07:57 PM
(16-07-2014, 07:31 PM)ClaraKay Wrote: Interesting chart in your previous post, Lotus. I have a question for you:
Where is DHT in the chart? Part of the available or unavailable testosterone? Or is it a separate thing altogether?
Clara
Good question, I doubt if one exists lol, it would come from free T, I remember seeing another figure somewhere on a slightly similar percentage.
Approximately 7% of testosterone is reduced to 5α-dihydrotestosterone (DHT) by the cytochrome P450 enzyme 5α-reductase, an enzyme highly expressed in male sex organs and hair follicles. Approximately 0.3% of testosterone is converted into estradiol by aromatase (CYP19A1) an enzyme expressed in the brain, liver, and adipose tissues.
Here's something interesting,
The total estradiol production rate in the human male has been estimated to be 35-45 μg (0.130-0.165 μmol) per day, of which approximately 20% is directly produced by the testes. Roughly 60% of circulating estradiol is derived from direct testicular secretion or from conversion of testicular androgens. The remaining fraction is derived from peripheral conversion of adrenal androgens.