[-Clelia-]

That's a good find, Clelia. Thanks!

happy you appreciate, you're welcome

what's your opinion?, sorry.... I've listed like 10 issues lol.

yep, lot of stuff to read here ... i'm reading everything you reported.
I will answer later on.

The first thing that I want to say is...
I spent an afternoon trying to understand this:

In this study, we investigated whether development of the murine mammary gland could be altered by stimulating or suppressing androgen receptor (AR) signaling in vivo. Intact virgin female mice aged 5 wk (midpuberty) or 12 wk (postpuberty) were implanted with slow-release pellets containing either placebo, 5α-dihydrotestosterone (1.5 mg) or the AR antagonist flutamide (60 mg). Treatment with 5α-dihydrotestosterone from midpuberty to 12 wk of age-retarded ductal extension by 40% (P = 0.007), but treatment from 12-21 wk had no significant effect on gland morphology. In contrast, inhibition of AR signaling with flutamide from midpuberty had no effect on the mammary gland, but flutamide treatment from 12-21 wk increased ductal branching (P = 0.004) and proliferation (P = 0.03) of breast epithelial cells. The increased proliferation in flutamide-treated mice was not correlated with serum estradiol levels or estrogen receptor-α (ERα) expression.

http://www.ncbi.nlm.nih.gov/pubmed/21846805

moreover: In control mice, the frequency and intensity of AR immunostaining in mammary epithelial cells was significantly increased in the 12- to 21-wk treatment group compared with the 5- to 12-wk group (P < 0.001). In contrast, no change in ERα occurred, resulting in a marked increase in the AR to ERα ratio from 0.56 (±0.12) to 1.47 (±0.10).
--> this means that receptor ERalfa is in the same quantity, in midpuberty and postpuberty. In contrast, AR receptor triple from middlepuberty to post-puberty, and that's why breast stop to grow in female (because AR receptors increase a lot).

Also we see from your favourite article that male rats depleted of AR receptors, develop full mammary gland.

So we see how important is AR signals in breast size (despite everything else).

What i do not understand up there underlined is:
why addiction of DHT didn't decrease gland morphology in adult mammary gland?
why affected just the midpuberty, retarding development?
maybe in the adult mammary gland, DHT in extra amount, is it converted in 3-diol? so it can neutralize is own androgenic effect? I don't know...maybe it's that back-door effect, but result is not estrogenic, otherwise mammary gland should have developed..

I could understand just flutamide action... in midpuberty should work less because of less presence of AR receptor. When AR receptors increase in post-puberty, the antagonism of them promote growing.

If we low DHT, we should mimic a bit flutamide action. And also, more testosterone will be converted in estradiol, as mentioned in your sign

Circulating 2-hydroxy and 16-α hydroxy estrone levels and risk of breast cancer among postmenopausal women

Thank you about this information, i read the abstract but i didn't get it... it talks about a ratio between two components, but i don't see what ratio. I will open the pdf... but not now... (no time left), btw, do you know if there is something that low this risk?

On another note....I've seen that EPA and DHA reduces the risk of breast cancer by as much as a 32% reduction, I don't know the dosage.

the article you posted says:
"The purpose of the WHEL Study was to assess whether a major increase in vegetable, fruit, and fiber intake and a decrease in dietary fat intake reduces the risk of recurrent and new primary breast cancer and all-cause mortality among women with previously treated early-stage breast cancer.
Women with higher intakes of EPA and DHA from food had an approximate 25% reduced risk of additional breast cancer events, compared with the lowest tertile of intake. Women with higher intakes of EPA and DHA from food had a dose-dependent reduced risk of all-cause mortality. EPA and DHA intake from fish oil supplements was not associated with breast cancer outcomes. The investigation indicates that marine fatty acids from food are associated with reduced risk of additional breast cancer events and all-cause mortality. J. Nutr. 141: 201–206, 2011."
maybe you can find the answer at your question in this table:

   

" Anti-androgenic activity of fatty acids." http://www.ncbi.nlm.nih.gov/pubmed/19353546 (2009)

Great link, thank you so much, I can only think of two supplements that cam meet that demand........coconut oil and EPO-evening primrose oil.

and hemp seed oil

I've got to go now. I know that i still miss something, i'll come back next week, i'm off for the weekend. see you!