11-03-2015, 02:10 AM
I think we have it, yay!!!, it's in line with what we've been saying about the high dosages. This is a very detailed study from 2006, (it's what we've been looking for, I'll post some telling details).
Phytoestrogens and breast cancer –promoters or protectors?
Short-term dietary supplementation has been shown to have proliferative effects on breast tissue in premenopausal women with breast tumors (not in women without breast disease) and animal studies have provided conflicting data as to whether phytoestrogens stimulate or inhibit chemically induced tumors or tumor implants. Generally, high concentrations of phytoestrogens are required to inhibit specific steroidogenic enzymes and hence local production of oestrogens that could be important in oestrogen-dependent breast cancers. Therefore, there is experimental evidence for both a promotional and a protective effect of phytoestrogens on breast cancer, but at the present time it is impossible to reconcile dietary/supplement exposure with epidemiological and experimental studies. Of major concern is that phytoestrogen supplements are over-the-counter drugs and women who do not find relief of menopausal symptoms with recommended dosages may simply up the dose of such ‘natural’ alternatives and achieve circulating concentrations of these compounds that may have deleterious effects on their health. Further work is required to determine the cellular actions of phytoestrogens beyond the oestrogen receptor and the effects of combinations of different phytoestrogens during long-term exposure.
http://erc.endocrinology-journals.org/co...4/995.full
Phytoestrogens and breast cancer –promoters or protectors?
Short-term dietary supplementation has been shown to have proliferative effects on breast tissue in premenopausal women with breast tumors (not in women without breast disease) and animal studies have provided conflicting data as to whether phytoestrogens stimulate or inhibit chemically induced tumors or tumor implants. Generally, high concentrations of phytoestrogens are required to inhibit specific steroidogenic enzymes and hence local production of oestrogens that could be important in oestrogen-dependent breast cancers. Therefore, there is experimental evidence for both a promotional and a protective effect of phytoestrogens on breast cancer, but at the present time it is impossible to reconcile dietary/supplement exposure with epidemiological and experimental studies. Of major concern is that phytoestrogen supplements are over-the-counter drugs and women who do not find relief of menopausal symptoms with recommended dosages may simply up the dose of such ‘natural’ alternatives and achieve circulating concentrations of these compounds that may have deleterious effects on their health. Further work is required to determine the cellular actions of phytoestrogens beyond the oestrogen receptor and the effects of combinations of different phytoestrogens during long-term exposure.
http://erc.endocrinology-journals.org/co...4/995.full