[Lotus]

Well the dosage part I'm not sure about yet, but if we go by binding affinity this applies:

High-affinity ligand binding implies that a relatively low concentration of a ligand is adequate to maximally occupy a ligand-binding site and trigger a physiological response.

Binding affinity data alone does not determine the overall potency of a drug. Potency is a result of the complex interplay of both the binding affinity and the ligand efficacy. Ligand efficacy refers to the ability of the ligand to produce a biological response upon binding to the target receptor and the quantitative magnitude of this response. This response may be as an agonist, antagonist, or inverse agonist, depending on the physiological response produced.[8]

http://wikipedia.org/wiki/Ligand_(biochemistry)

But the amount (dosage) will be be different in men and women, some of the recommendations say low dose in men counters prolactin release, while higher dosages inhibit it.

Take for instance this study:

Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.

In premenstrual dysphoric disorder, one study reported Vitex to be equivalent to fluoxetine, while in the other, fluoxetine outperformed Vitex. In latent hyperprolactinaemia, one trial reported it to be superior to placebo for reducing TRH-stimulated prolactin secretion, normalising a shortened luteal phase, increasing mid-luteal progesterone and 17β-oestradiol levels, while the other found Vitex comparable to bromocriptine for reducing serum prolactin levels and ameliorating cyclic mastalgia.
http://www.ncbi.nlm.nih.gov/pubmed/23136064

So we really need to be careful with recommendations. But, I still want more info on vitex, but it "is" a phytoestrongen.

The concerns about vitex centers around how it influences dopamine, but I think this can (vitex) goes deeper than that, I believe it also plays a big part in lipid oxidation, which is huge because that ties into anti-inflammtories, free radical scavengers, degenerative conditions and of course Eicosanoid Pathway, which involves COX inhibitors (big time aromatase).

You know the view or shoud I say the research over the last decade or two has shown that fatty acids are a preventive measure against cancer. So, there's plenty of debate for sure, I certainly won't try to change someone's mind about it, I'll just refer them to research, like I did, I was completely against increased intake of FFA's, and I was in the industry for 30 years.

I will say this, if you don't have fitness in a NBE plan and take this approach you'd better be prepared to get chunky, cause fat loves making more fat.