[Troublewithnibbles]

So forskolin will inhibit PDE without the help of other PDE inhibitors?

[Lotus]

So forskolin will inhibit PDE without the help of other PDE inhibitors?

It does, but there's another phosphodiesterase inhibitor I find interesting...aloe vera. 
https://www.researchgate.net/publication/256539509_Chemical_constituents_of_Aloe_barbadensis_Miller_and_their_inhibitory_effects_on_phosphodiesterase-4D

Somatostatin inhibits oral estradiol, prolactin, growth hormone and stomach gastrin. 

Somatostatin stimulates insulin, which has deleterious effects to breast growth. So, the new goal needs to inhibit somatostatin. Somatostatin also inhibits the cAMP/PKA/CREB pathway...which is the breast growth pathway. 

More info to follow bringing all this into focus.

[Stevenator.]

>More info to follow bringing all this into focus.

AWOO!

[Lotus]

>More info to follow bringing all this into focus.

AWOO!

Ok so bringing this into focus. A few years ago I posted some information (shared below) regarding cimetidine and how it inhibits stomach gastrin and thereby increases estradiol. Cimetidine and H2 inhibitors aren't the only game in town that inhibits gastrin. Forskolin and aloe vera and some other agents inhibit gastrin. Explaining what somatostatin does is explained in the link below. Trust me when I say somatostatin is about as bad for breast growth as DHT. In closing, inhibiting somatostatin seems to up our game for promoting breast growth. One final note about forskolin, it improves thyroid function, so much so in my case it reversed my hashimoto's of 15 years.

Somatostatin 
http://www.vivo.colostate.edu/hbooks/pat...tatin.html

Using H2 Blockers (H2-receptor antagonists) and to a lesser extent H1 receptors antagonists block stomach acid (aka. gastrin) increase plasma estradiol and prolactin.  Drugs like cimetidine and ranitidine (others too) inhibit stomach acid, though ranitidine to a lesser extent nukes the cytochrome (CYP) P450 enzymes. Cimetidine is for a short time (I believe 2-4weeks) to treat stomach acid. If you have normal stomach acid cimetidine and the like aren't necessary, as always consult a health professional.

https://www.breastnexum.com/showthread.php?tid=17436&pid=196127&highlight=cimetidine#pid196127
Post # 3990..

This study demonstrates that the administration of cimetidine to men decreases the 2-hydroxylation of estradiol and results in an increase in the serum estradiol concentration.

The Effects of Cimetidine on the Oxidative Metabolism of Estradiol
https://www.researchgate.net/publication..._Estradiol

[Troublewithnibbles]

And how exactly do we inhibit somatostatin?  I read this multiple times and didn’t pick up on that bit.

[Stevenator.]

Bad Link on the Cimetidine. 
What dosage levels are you referring to with Tagamet?

[Lotus]

And how exactly do we inhibit somatostatin?  I read this multiple times and didn’t pick up on that bit.

Melatonin and Phosphatidylcholine or Alpha GPC or CDP-choline help to inhibit somatostatin. Melatonin is 1-3mg and alpha GPC at 1200mg. I'm looking into a few other options too, I'll post that info when I find out more.

[Lotus]

Bad Link on the Cimetidine. 
What dosage levels are you referring to with Tagamet?

400mg, stay away from using cimetidine to boost estradiol...it's not worth the side effects.
https://pubmed.ncbi.nlm.nih.gov/2747769/

[Stevenator.]

I did a deep dive into Cimetidine last year, reading countless research articles about the stuff, but this paper is new to me. It’s quite an interesting drug, with tons of side effects and properties. Thank you.

[Troublewithnibbles]

And how exactly do we inhibit somatostatin?  I read this multiple times and didn’t pick up on that bit.

Melatonin and Phosphatidylcholine or Alpha GPC or CDP-choline help to inhibit somatostatin. Melatonin is 1-3mg and alpha GPC at 1200mg. I'm looking into a few other options too, I'll post that info when I find out more.

So melatonin will help me sleep AND grow?  Sounds like a win-win!