30-01-2014, 05:26 PM
fuffing fuf fuff !!
now i am totally lost
can someone lend me their brains
now i am totally lost
can someone lend me their brains
(30-01-2014, 04:41 PM)ClaraKay Wrote: This subject is very interesting, but I'm confused.
Aromatase is an enzyme that is needed to convert testosterone to estrogen in males. Which T is converted to which E? Is it free T that is converted to estradiol, or DHT?
About 90% of testosterone is produced by the testes; the remainder is produced by the adrenal glands. Non-protein bound testosterone is not constrained; however, only 2 percent of the testosterone that a man has, and 1 percent in a woman, is free or non-protein bound. In both men and woman, more than half of the total circulating testosterone is constrained by SHBG, which is sex hormone-binding globulin. The majority of the remaining testosterone is bound to albumin.
How does DHT protect against estrogen? There are at least three ways that this likely occurs. First of all, DHT directly inhibits estrogens activity on tissues. It either does this by acting as a competitive antagonist to the estrogen receptor or by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding.
Second of all, DHT and its metabolites have been shown to directly block the production of estrogens from androgens by inhibiting the activity of the aromatase enzyme. The studies done in breast tissue showed that DHT, androsterone, and 5alpha-androstandione are potent inhibitors of the formation of estrone from androstenedione. 5alpha-androstandione was shown to be the most potent, while androsterone was the least.
Lastly, DHT acts on the hypothalamus / pituitary to decrease the secretion of gonadotropins. By decreasing the secretion of gonadotropins you decrease the production of the raw materials for estrogen production – testosterone and androstenedione (DHT itself cannot aromatize into estrogens). This property of DHT comes into particular utility when it is administered exogenously, and this is to be discussed in further detail in the next section.
For the geeks
http://www.ncbi.nlm.nih.gov/pmc/articles...ool=pubmed
http://press.endocrine.org/doi/full/10.1....2006-2203
http://forum.bodybuilding.com/showthread.php?t=134536051&page=3
To what extend are either Spearmint (which is anti-free T) or Pygeum (which is anti-DHT) going to complete with WP (a pro-aromatase herb whose purpose is to convert T to E)?
Your binding the DHT with Spearmint and Pygeum (preventing from becoming DHT,), the WP Converts what you do have available to be E.
Also, to what extend is an aromatase promoting herb like White Peony interfering with PM? The theory is that estradiol and miroestrol compete for the same estrogen receptors in breast tissue. The more powerful estradiol, increases the risk of developing a malignant tumor in the breast. Miroestrol (the estrogen mimic in PM) is weaker, and by displacing estradiol, lowers the risk of cancer of the breast. Doesn't that mean that we should be favoring PM for NBE over pro-aromatase herbs like WP?
http://chineseherbinfo.com/bai-shao-yao-...eony-root/ Big file! Careful!
descriptive-
I hope some one can set me straight on this because I'm planning to make a change in my program next week (currently PM + Spearmint) by adding Pygeum (an anti-5 alpha reductase).
And, Lisa Lou, if you read this...you wrote that you're planning to replace SP with Spearmint+WP, right? What is your reasoning behind choosing WP over, say, Pygeum?
Clara Kay
(30-01-2014, 04:41 PM)ClaraKay Wrote: This subject is very interesting, but I'm confused.Pygeum - pygeum extract is the most popular treatment for BPH. When compared with saw palmetto in a clinical trial, it was demonstrated that saw palmetto produced greater reduction of symptoms and was better tolerated. However, PAE may have greater effects on prostate secretion. By improving an underlying problem, PAE may improve sexual function. Pygeum clinical trials (mostly European) are encouraging, but more research is needed in the US.
I hope some one can set me straight on this because I'm planning to make a change in my program next week (currently PM + Spearmint) by adding Pygeum (an anti-5 alpha reductase).
(30-01-2014, 05:51 PM)ClaraKay Wrote: Also, to what extend is an aromatase promoting herb like White Peony interfering with PM? The theory is that estradiol and miroestrol compete for the same estrogen receptors in breast tissue. The more powerful estradiol, increases the risk of developing a malignant tumor in the breast. Miroestrol (the estrogen mimic in PM) is weaker, and by displacing estradiol, lowers the risk of cancer of the breast. Doesn't that mean that we should be favoring PM for NBE over pro-aromatase herbs like WP?