31-01-2023, 05:46 AM
(31-01-2023, 05:01 AM)Lotus Wrote:(29-01-2023, 09:04 PM)Gabrielle Wrote: we all know about hops. from the consumption of mans best friend, which results in moobs.
(29-01-2023, 08:32 PM)NuqueNilex Wrote: I made a post if you want to see the supplements i am taking. and sorry for the long post.
Here's some research i put together on hops
https://www.breastnexum.com/showthread.php?tid=17436&pid=219638#pid219638
(04-09-2016, 11:32 PM)Lotus Wrote: Hi Marcy,
From the studies I've seen, HOPS is 70 times more potent for ER-b (estrogen receptor beta) over estradiol and 20,000 times less potent at ER-a (estrogen receptor alpha) over estradiol. If I didn't mention already, HOPS upregulates progesterone receptor mRNA (signaling)..a ten-fold increase in PR gene upregulation. Besides stimulating IGF-1 HOPs enhances thermogenesis in BAT (brown adipose tissue, aka " fat " ), which means counteracting increases body fat......I know right, I'm thinking beer means beer belly imo, didn't make sense, but here's the study.
http://www.ncbi.nlm.nih.gov/m/pubmed/26098641/
FWIW I don't think HOPS will comprise HRT, for me I'd take it at night time for the IGF-1 stimulation and promotion of PR (progesterone receptor).
Hop and red clover extracts, as well as 8-PN upregulated progesterone receptor (PR) mRNA in the Ishikawa cell line. In the MCF-7 cell line, PR mRNA was significantly upregulated by the extracts, biochanin A, genistein, 8-PN, and IX. The two extracts had EC50 values of 1.1 and 1.9 μg/mL, respectively, in the alkaline phosphatase induction assay. Based on these data, hops and red clover could be attractive for development as herbal dietary supplements to alleviate menopause-associated symptoms.
http://www.ncbi.nlm.nih.gov/pmc/articles...s14948.pdf
Plus other HOPS info
https://www.breastnexum.com/showthread.php?tid=17436&pid=219638#pid219638
Everything said about hops is wrong. Hops activate and prefer ERalpha more than ERbeta. Hopien, the phyto-estrogen that acts like Estradiol, is 70 times less potent than 17-beta Estradiol. Hops like to attach to ERalpha WAY more than ERbeta. This is why I do my own research when I read stuff from here.
https://www.herbalgram.org/resources/her...view44569/
"Milligan and his team isolated and characterized '8PN as the major estrogenic substance in hops and one of the most potent known plant estrogens.' Subsequent research has demonstrated that 8PN mimics the action of 17beta-estradiol. 8PN has 10-20,000-fold less potency than estradiol for ERbeta. However, it has a much greater affinity for the ERalpha receptor, where it is only 70-fold less potent than estradiol. When racemic 8PN is separated and assayed, there is 'no significant difference in ER binding potency between the 2R and 2S forms."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815392/
"The red clover extract preferentially bound to the ERβ receptor nine-times greater than to ERα. The hop extract had nearly a two-fold preference for ERα compared with ERβ. Since all of these studies were carried out using cell-based assays with ERα positive cell lines, it is important to note that the hop and red clover extracts had equivalent ERα activity."