[Lotus]

ok i am trying to catch up with this thread (halfway through on another separate tab). 

ok while i muddle through the rest of the 80 something pages   i have a few questions regarding dht reduction and what i post below is what i am currently using (about a half a dropper full) :

reishi for dht reduction (how many times  a day? 

its liquid extract
White peony for aromatization (same thing, how many times a day its also liquid extract)


and SHOULD i also add green tea extract too? does two of the same contradict each other or compete?

Sorry a lot of questions all bottled up in one post. 

Hi TMS, someone asked me a similar question (to yours) and this was my response:

Pueraria Mirifica – Awesome for breast growth

Reishi-reishi mushrooms – Significantly reduced levels of 5-alpha reductase, preventing conversion of testosterone into the more potent DHT. High levels of DHT are a risk factor for conditions such as benign prostatatic hypertrophy (BPH), acne, and baldness.

White Peony – Estrogenic, blocks 5ar and pro-aromatase - Strong.
A compound found in white peony inhibits the production of testosterone and promotes the activity of aromatase, which converts testosterone into estrogen.

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Th above is what I've been reading on this thread. My question is: Should one combine PM with both RM AND WP? Does WP & RM not do the same thing? Why take both in a HRT program? Or am I missing something?

Both are similar, however...there's significant differences. From the research I've covered, Reishi Inhibits type I & II 5ar....and WP binds androgen receptors. When I took Reishi I could 4-5 days without needing a shave. Now, on HRT I need a shave within 2 days...and that's with my T and free T being non-existent, so go figure. 

WP needs to be standardized to contain a minimum of 10% Paeoniflorin (solaray has one i believe). Total glucosides of peony (TGP), contains more than 15 components, BUT Paeoniflorin is the most abundant ingredient and NEEDS to be 90% of the total glucosides. 

There's about a gazillion scientific papers on WP and its benefits. I've posted most of what I think is beneficial for NBE here (at BN). In the BN search engine, insert Lotus into the username and check the box for posts (not threads) and you find what I've shared. 

Using WP and Reishi together works synergistically IMHO. 

"Using WP and Reishi together works synergistically IMHO."

Thank you! I get it. This stuff is very complicated but I'll take both WP & RM on your recommendation.    

Bev

Thanks for any reply (hopefully an in depth one).

The dosage for White Peony that worked for me was 2 grams, make sure you get the highest standardized WP possible.

Reishi- in its own right does feminize, and has an aromatase study, I'd have to find it though. As far as dosage i take mine as tea. Which for me is ¼ teaspoons with my coffee in the morning. In liquid extract or pill form just follow the manufacturer's suggested dosage. 

Honestly though, I'd stick with GTE and reishi. If you want something "NEW and Extraordinary" though pm me and you'll be among a select few I'm sharing it with that blows the door off any known pro-aromatase. 

Someone shared the WP content of Swanson's brand a while back (my apologies to the OP I don't remember who though). White peony (standardized) should bump aromatase 2-3 fold (based on scientific literature) a 30% increase, for myself that means an increase of 60-80 pg/mL blood estradiol, though everybody is different. I believe Life Extension sells a standardized capsule but Swanson full spectrum isn't standardized. I believe it's not standardized (lol, I have a bottle sitting on the shelf too). Here's a few things about WP, or where I think the rubber needs to meet the road, or more to the point finding a suitable WP supplement that contains two compounds: 6'-O-galloyl  and pentagalloylglucose, they bind androgen receptors and inhibit DHT. Let's let science solve this puzzle of what WP does for NBE.....which I think we just did. The dose could be less than I calculated earlier if these compounds and the main glycoside 3'-O-galloyl paeoniflorin are present would be estimated at 1 gram. 

Additionally, testosterone/delta 4-androstenedione production ratio is also reduced (significantly) by paeoniflorin (white peony). 

In ovaries WP promotes aromatase, (I believe in the breasts too), inhibits DHT in sebum, inhibits prostate cancer cells, (which means it inhibits C17 @ CYP17 P450 enzyme, a strong anti-androgen. The lab dosage was 2 grams (I'll have to double check). Roots contain the highest bioactives.

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Androgen modulators from the roots of Paeonia (paeoniae radix) grown and processed in nara prefecture, Japan.
Washida K1, Itoh Y, Iwashita T, Nomoto K.
Abstract
The monoterpene glycoside, 3'-O-galloyl paeoniflorin (1), and four known compounds, 6'-O-galloyl  (2), pentagalloylglucose (3), 6'-O-benzoyl paeoniflorin (4) and 6'-O-galloyl paeoniflorin (5), were isolated from the roots of Paeonia  that had been grown and processed in Nara prefecture, Japan, as androgen modulators. Their structures were elucidated based on spectroscopic analysis. Compounds 2 and 3 showed strong androgen receptor (AR) binding activity (IC(50) values 33.7 and 4.1 microg/ml, respectively), 1, 4 and 5 showed weak activity (20, 31 and 12% at 120 microg/ml, respectively). However, paeoniflorin (6) and albiflorin (7), the structures of which are related to 1, 2, 4 and 5, showed no activity. These results suggested that both the structure of albiflorin and the galloyl moiety are important for 2 to show strong AR binding activity. Furthermore, compounds 1-5 inhibited growth of an androgen-dependent LNCaP-FGC (prostate cancer cell line), and were indicated to be AR antagonists. Compounds 2 and 3 might be candidates as safe, natural anti-androgens.

Testosterone/delta 4-androstenedione production ratio was lowered significantly by paeoniflorin, and two compounds, 6'-O-galloyl  and pentagalloylglucose bind androgen receptors and inhibit DHT.